Citrate Azide Tween®Carbonate (CATC) Agar
- Document Type:
- Data Sheet
acide
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Mouse IgG, Azide Free (1mg) KC Blocking Reagent
- Document Type:
- Certificate of Analysis
- Lot Number:
- 1424382-6
- Product Catalog Number:
- PP54Z-KC
- Product Catalog Name:
- Mouse IgG, Azide Free (1mg) KC
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101590 Azide Dextrose Broth
- Document Type:
- Technical Information
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Mouse Serum (Sodium Azide Free) Ammonium Sulfate Fractionated - LV1917405
- Document Type:
- Certificate of Analysis
- Lot Number:
- LV1917405
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Effect of trans-2,3-dimethoxycinnamoyl azide on enhancing antitumor activity of romidepsin on human bladder cancer.
- Romidepsin (FK228, depsipeptide, FR901228), a unique cyclic depsipeptide with a histone deacetylase inhibitor (HDACI) activity, is a potential cancer therapeutic agent and currently under clinical trials for several types of cancer. For bladder cancer, romidepsin seems to be a potent antitumor agent from our recent study. In this study, we further delineate a new agent that can enhance both HDACI and antitumor activity of romidepsin.We screened a chemical library to identify candidate(s) that could enhance romidepsin activity. Chemical synthesis and purification were carried out to produce pure compound to examine its biochemical and antitumor effect on bladder cancer cell lines both in vitro and in vivo.Tranilast, N-(acetoacetyl) anthranilic acid, was first identified as a lead compound from screening, and then, one of the analogues, 2,3-dimethoxycinnamoyl azide (DMCA), seems to be more potent than tranilast. Our data indicate that DMCA can potentiate the HDACI activity of romidepsin and other biological activities, such as cell cycle arrest and apoptosis; these effects were accompanied with the expression of various key cell cycle regulators in different bladder cancer cells. Consistently, DMCA can enhance the in vivo antitumor effect of romidepsin without causing any more weight loss than romidepsin alone.DMCA is able to enhance the antitumor effect of romidepsin on bladder cancer from in vitro and in vivo.
- Document Type:
- Reference
- Product Catalog Number:
- 17-371
- Product Catalog Name:
- EZ-ChIP™
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CATC Agar (Citrate Azide Tween Carbonate) Base, 110279
- Document Type:
- Technical Information
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Anti-Trop2, clone 2EF, Azide Free Monoclonal Antibody
- Document Type:
- Certificate of Analysis
- Lot Number:
- 3127628
- Product Catalog Number:
- MABC518
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Anti-uPAR, clone 3C6 (Azide Free) Monoclonal Antibody
- Document Type:
- Certificate of Analysis
- Lot Number:
- 3150349
- Product Catalog Number:
- MABC89
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Anti-SDF-1, clone K15C, Azide free Monoclonal Antibody
- Document Type:
- Certificate of Analysis
- Lot Number:
- 2885551
- Product Catalog Number:
- MABC184
- Product Catalog Name:
- Anti-SDF-1 Antibody, clone K15C, Azide free
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Anti-TIM-3, clone RMT3-23, Azide Free Monoclonal Antibody
- Document Type:
- Certificate of Analysis
- Lot Number:
- 2886335
- Product Catalog Number:
- MABF230
- Product Catalog Name:
- Anti-TIM-3, clone RMT3-23, Azide Free Antibody