707066
DCA Deblock (0.36M dichloroacetic acid in toluene)
Synonym(s):
DCA Deblock, DEBLOCK (0.36M dichloroacetic acid in toluene)
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About This Item
Empirical Formula (Hill Notation):
C2H2Cl2O2
CAS Number:
Molecular Weight:
128.94
UNSPSC Code:
12352106
PubChem Substance ID:
MDL number:
Concentration:
≤100 ppm in H2O
Form:
liquid
form
liquid
Quality Segment
concentration
≤100 ppm in H2O
bp
110-111 °C
density
0.884 g/mL at 25 °C
SMILES string
OC(=O)C(Cl)Cl
InChI
1S/C2H2Cl2O2/c3-1(4)2(5)6/h1H,(H,5,6)
InChI key
JXTHNDFMNIQAHM-UHFFFAOYSA-N
General description
Deblock solution, containing dichloroacetic acid (DCA) in dichloromethane or Toluene, removes the dimethoxytrityl (DMT) protecting the group from the 5′ hydroxyl moiety of nucleotides already incorporated into the growing nucleic acid, prior to the addition of the next phosphoramidite. Removal of the DMT allows the unprotected 5′ hydroxyl moiety to react with a new phosphoramidite in a subsequent extension reaction.
Application
DCA Deblock (0.36M dichloroacetic acid in toluene) is suitable for the removal of 4,4Adimethoxytrityl (DMTr) protecting groups for the synthesis of antisense oligonucleotides in high yield and purity.
signalword
Danger
Hazard Classifications
Aquatic Chronic 3 - Asp. Tox. 1 - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Lact. - Repr. 1B - Skin Irrit. 2 - STOT RE 2 Inhalation - STOT SE 3
target_organs
Central nervous system
Storage Class
3 - Flammable liquids
wgk
WGK 3
flash_point_f
41.0 °F
flash_point_c
5 °C
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
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