34218
Cefuroxime
VETRANAL®, analytical standard
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About This Item
Empirical Formula (Hill Notation):
C16H16N4O8S
CAS Number:
Molecular Weight:
424.39
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
259-560-1
MDL number:
grade
analytical standard
Quality Level
product line
VETRANAL®
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
clinical testing
format
neat
storage temp.
2-8°C
SMILES string
[H][C@]12SCC(COC(N)=O)=C(N1C(=O)[C@H]2NC(=O)\C(=N/OC)c3ccco3)C(O)=O
InChI
1S/C16H16N4O8S/c1-26-19-9(8-3-2-4-27-8)12(21)18-10-13(22)20-11(15(23)24)7(5-28-16(17)25)6-29-14(10)20/h2-4,10,14H,5-6H2,1H3,(H2,17,25)(H,18,21)(H,23,24)/b19-9-/t10-,14-/m1/s1
InChI key
JFPVXVDWJQMJEE-IZRZKJBUSA-N
General description
Chemical structure: β-lactam
Cefuroxime is a new broad-spectrum cephalosporin antibiotic, with increased stability to β-lactamases. It is actively used against gram-positive organisms, including penicillinase-producing staphylococci and non-β-lactamase-producing gram-negative bacteria.
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Cefuroxime may be used as a reference standard in the determination of cefuroxime in plasma samples using high-performance liquid chromatography (HPLC).(3)
Legal Information
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
Eyeshields, Gloves, type N95 (US)
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Simon Farnebo et al.
Biomedicines, 8(10) (2020-10-16)
Uncomplicated healing of grafts for tendon reconstruction remains an unsolved problem in hand surgery. Results are limited by adhesion formation and decreased strength properties, especially within the tight fibro-osseous sheath of the digits. This is especially problematic when an extra
Cefuroxime, a new cephalosporin antibiotic: activity in vitro.
O'Callaghan HC, et al.
Antimicrobial Agents and Chemotherapy, 9(3), 511-519 (1976)
Dandan He et al.
Antimicrobial agents and chemotherapy, 60(10), 6084-6090 (2016-08-03)
Clinical isolates producing hybrid CTX-M β-lactamases, presumably due to recombination between the blaCTX-M-15 and blaCTX-M-14 elements, have emerged in recent years. Among the hybrid enzymes, CTX-M-64 and CTX-M-14 display the most significant difference in catalytic activity. This study aims to