H4125
Hesperetin
analytical standard
Synonym(s):
3′,5,7-Trihydroxy-4′-methoxyflavanone, 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-chromanone
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About This Item
Empirical Formula (Hill Notation):
C16H14O6
CAS Number:
Molecular Weight:
302.28
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
grade
analytical standard
Quality Level
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
food and beverages
format
neat
storage temp.
2-8°C
SMILES string
COc1ccc(cc1O)C2CC(=O)c3c(O)cc(O)cc3O2
InChI
1S/C16H14O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-6,14,17-19H,7H2,1H3
InChI key
AIONOLUJZLIMTK-UHFFFAOYSA-N
General description
Hesperetin is an aglycon form of flavonoid, which can be found in peels of citrus fruits.
Application
Hesperetin has been used as a standard in studies involving the cytotoxic effect of hesperetin on doxorubicin-resistant MCF-7 cells using enzyme-linked immunosorbent assay (ELISA) technique.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Biochem/physiol Actions
Dietary flavanone with chemopreventive effect.
Other Notes
For this product we use the non-stereospecific CAS number. It is expected that the natural enantiomer is predominant, however the substance is prone to racemization in solution. The product is therefore not specified stereospecifically and is only recommended to be used for non-stereospecific analysis.
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Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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Increasing sensitivity of MCF-7/DOX cells towards doxorubicin by hesperetin through suppression of P-glycoprotein expression
Sarmoko, et al.
Indonesian Journal of Pharmacy, 25, 84-84 (2014)
Manoj Aswar et al.
Pharmacology, biochemistry, and behavior, 124, 101-107 (2014-05-30)
Behavioral, biochemical and gene expression changes were investigated in a rat model of partial sciatic nerve ligation (PSNL) after administration of hesperetin (20, 50mg/kg; p.o.), pregabalin (10mg/kg; p.o.) or vehicle (1 ml/kg, p.o.). Thirty-six animals were randomly divided into six
Benjamin Dilberger et al.
Nutrients, 11(8) (2019-08-16)
(1) Background: Polyphenols (PP) play an important role in the prevention of non-communicable diseases and may contribute to healthy aging. To investigate the molecular and cellular aspects of PP metabolites on longevity with a focus on mitochondrial function, we applied