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S8534

Sarsasapogenin

≥98%

Synonym(s):

(25S)-Spirostan-3β-ol, Parigenin

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About This Item

Empirical Formula (Hill Notation):
C27H44O3
CAS Number:
126-19-2
Molecular Weight:
416.64
NACRES:
NA.25
PubChem Substance ID:
24899798
UNSPSC Code:
12352200
EC Number:
204-776-3
MDL number:
MFCD00270414
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Quality Segment

200

assay

≥98%

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

SMILES string

C[C@H]1CC[C@@]2(OC1)O[C@H]3C[C@H]4[C@@H]5CC[C@@H]6C[C@@H](O)CC[C@]6(C)[C@H]5CC[C@]4(C)[C@H]3[C@@H]2C

InChI

1S/C27H44O3/c1-16-7-12-27(29-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(28)8-10-25(18,3)21(20)9-11-26(22,24)4/h16-24,28H,5-15H2,1-4H3/t16-,17-,18+,19-,20+,21-,22-,23-,24-,25-,26-,27+/m0/s1

InChI key

GMBQZIIUCVWOCD-WWASVFFGSA-N

General description

Sarsasapogenin also known as Sarsagenin or Parigenin, is a steroidal saponin and is the main constituent of Anemarrhena asphodeloides Bunge.

Application

Sarsasapogenin has been used as a synthetic saponin treatment to U-2 OS cells to test its effects in reducing osteosarcoma cell viability and down-regulating YAP and TAZ proteins.

Biochem/physiol Actions

Sarsasapogenin is a well-known multi-target directed ligand (MTDL) for Alzheimer′s disease. It elicits anti-inflammatory, antioxidant, anti-arthritis, anti-asthma, anti-amyloidogenic, neuroprotective, anti-depressant, and anti-cancer properties. SAR also improves learning and memory ability, loss of neurons in type-1 diabetic rats and protects against diabetic encephalopathy. It is also a therapeutic target for treating ulcerative colitis (UC). SAR as an anti-inflammatory agent improves insulin resistance and adipose tissue inflammation in high-fat diet (HFD)-fed mice.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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