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SML4215

Lipofermata

≥98% (HPLC), powder, FATP2 (SLC27A2) inhibitor

Synonym(s):

5′-Bromo-5-phenyl-spiro[3H-1,3,4-thiadiazole-2,3′-indoline]-2′-one, CB 16.2, CB16.2, CB-16.2

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About This Item

Empirical Formula (Hill Notation):
C15H10BrN3OS
CAS Number:
297180-15-5
Molecular Weight:
360.23
MDL number:
MFCD00770315
NACRES:
NA.21
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to light brown

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

SMILES string

O=C1NC2=CC=C(C=C2C13SC(C4=CC=CC=C4)=NN3)Br

Application

Lipofermata may be used to evaluate fatty acidtransport inhibition in Caco-2, HepG2, and C2C12 cell lines; and to studyits effect on LPS-induced inflammatory responses in whole blood and humanmonocytes.

Biochem/physiol Actions

Lipofermata (CB-16.2) is an orally active and selective long-chain fatty acid (LCFA) transport protein FATP2 (SLC27A2) inhibitor (IC50 in μM =2.74/HepG2, 4.65/INS-1E, 5.67/C2C12, 6.09/Caco2; IC50 = 39.34 μM in non-FATP2-expressing 3T3L1) with no effect against medium chain (C6-C10) fatty acids transport by passive diffusion. Lipofermata prevents palmitate-mediated oxidative stress and cell death in cultures (5-50 μM lipofermata against 500 μM palmitate; HepG2 and INS-1E cells) and prevents the absorption of 13C-oleate in mice in vivo (300 mg/mL lipofermata p.p. 1h prior to 500 mg/kg 13C-oleate p.o.).

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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