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MAB2638 Sigma-AldrichAnti-Integrin beta7 Antibody, clone TN114

Anti-Integrin beta7 Antibody, clone TN114 is an antibody against Integrin beta7 for use in FC, IP, IH.

Anti-Integrin beta7 Antibody, clone TN114 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书

Research Category: Cell Structure Research Sub-Category: Integrins Gene Symbol: ITGB7 UniProt Number: P26010

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概述

Replacement Information

特卖

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H	FC, IP, IHC	AHm	Purified	Monoclonal Antibody

Description
Catalogue Number	MAB2638
Description	Anti-Integrin beta7 Antibody, clone TN114
Alternate Names	integrin, beta 7 integrin beta 7 subunit Gut homing receptor beta subunit
Background Information	Integrin beta7 is an adhesion molecule belonging to the integrin beta chain family. It forms heterodimers with the alpha subunit, most notably the integrin alpha4 and alphaE subunits, functioning to mediate migration and homing of lymphocytes to the gut-associated lymphoid tissue (GALT). The heterodimer formed with alpha4, α4β7, is specifically involved in the homing and migration of lymphocytes to the gut, while αEβ7 is involved in the binding of T lymphocytes to epithelial cells and is induced by TGFβ1. Integrin beta7 has been observed in several different leukocyte lines.

References

Product Information
Format	Purified
Control	Human peripheral blood mononuclear cells (PBMC's).
Presentation	Purified armenian hamster monoclonal IgG in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level	MQ100

Applications
Application	Anti-Integrin beta7 Antibody, clone TN114 is an antibody against Integrin beta7 for use in FC, IP, IH.
Key Applications	Flow Cytometry Immunoprecipitation Immunohistochemistry

Biological Information
Immunogen	Purified human integrin beta7 protein.
Epitope	Unknown
Clone	TN114
Concentration	Please refer to the Certificate of Analysis for the lot-specific concentration.
Host	Armenian Hamster
Specificity	The antibody recognizes Integrin beta7.
Isotype	IgG
Species Reactivity	Human
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_000880.1
Gene Symbol	ITGB7
Purification Method	Protein G Purified
UniProt Number	P26010
UniProt Summary	FUNCTION: Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin. SUBUNIT STRUCTURE: Heterodimer of an alpha and a beta subunit. Beta-7 associates with either alpha-4 or alpha-E. Integrin alpha-4/beta-7 interacts with MADCAM1, VCAM, fibronectin, and may also interact with HIV-1 gp120. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Expressed in a variety of leukocyte lines. INDUCTION: Integrin alpha-E/beta-7 is induced by TGFB1. DOMAIN: Domain I contains three cation-binding sites: the ligand-integrin-binding site (LIMBS), the metal ion-dependent adhesion site (MIDAS), and the adjacent to MIDAS site (ADMIDAS). In the absence of a ligand or in calcium-dependent binding, only ADMIDAS is occupied. In magnesium-dependent binding all three sites bind metal ions. LIMBS positively modify ligand binding whereas ADMIDAS negatively modify ligand binding. SEQUENCE SIMILARITIES: Belongs to the integrin beta chain family. Contains 1 VWFA domain.
Molecular Weight	~ 86 kDa

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Flow Cytometry in human PBMC's. Flow Cytometry Analysis: 1 µg/mL of this antibody detected Integrin beta7 on human PBMC's.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 µg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
MAB2638	04053252288234

Documentation

Anti-Integrin beta7 Antibody, clone TN114 MSDS

职位
物料安全数据表 (MSDS)

Anti-Integrin beta7 Antibody, clone TN114 分析证书

标题	批号
Anti-Integrin beta7, clone TN114	2479803
Anti-Integrin beta7, clone TN114	2476756
Anti-Integrin beta7, clone TN114 - 2437711	2437711
Anti-Integrin beta7, clone TN114 - 1972818	1972818
Anti-Integrin beta7, clone TN114 - 2541555	2541555
Anti-Integrin beta7, clone TN114 - 3980281	3980281
Anti-Integrin beta7, clone TN114 - NRG1736368	NRG1736368
Anti-Integrin beta7, clone TN114 -2573685	2573685
Anti-Integrin beta7, clone TN114 -2621733	2621733
Anti-Integrin beta7, clone TN114 Monoclonal Antibody	2925720

种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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