5.04463
BINA
Synonym(s):
BINA, Biphenyl-indanone A
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Empirical Formula (Hill Notation):
C30H30O4
CAS Number:
Molecular Weight:
454.56
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
OK to freeze, protect from light
assay
≥98% (HPLC)
Quality Segment
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 18 mg/mL
storage temp.
2-8°C
InChI
1S/C30H30O4/c1-18-19(2)28-25(15-26(29(28)31)22-7-3-4-8-22)16-27(18)34-17-20-6-5-9-24(14-20)21-10-12-23(13-11-21)30(32)33/h5-6,9-14,16,22,26H,3-4,7-8,15,17H2,1-2H3,(H,32,33)
InChI key
KMKBEESNZAPKMP-UHFFFAOYSA-N
General description
A selective positive allosteric modulator for mGlu receptor subtype 2 (EC50 = 33.2 nM in CHO cells expressing human mGlu2). No effect on other mGlu receptor subtypes. Exhibits antipsychotic and anxiolytic properties in mice.
Biochem/physiol Actions
Primary Target
mGlu₂
mGlu₂
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Bonnefous, C., et al. 2005. Bioorg. Med. Chem. Lett.15, 4354.
Galici, R., et al. 2006. J. Pharmacol. Exp. Ther.318, 173.
Benneyworth, M., et al. 2007. Mol. Pharmacol.72, 477.
Sheffler, D., et al. 2011. ACS Chem. Neurosci.2, 382.
Galici, R., et al. 2006. J. Pharmacol. Exp. Ther.318, 173.
Benneyworth, M., et al. 2007. Mol. Pharmacol.72, 477.
Sheffler, D., et al. 2011. ACS Chem. Neurosci.2, 382.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.