143057
Aldrithiol™-4
98%
Sinónimos:
4,4′-Dipyridyl disulfide, 4,4′-Dithiodipyridine
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Acerca de este artículo
Fórmula empírica (notación de Hill):
C10H8N2S2
Número CAS:
Peso molecular:
220.31
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
220-158-6
MDL number:
Assay:
98%
Form:
solid
Servicio técnico
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Permítanos ayudarleQuality Level
assay
98%
form
solid
mp
76-78 °C (lit.)
solubility
95% ethanol: soluble 5%, clear, colorless to light yellow
functional group
disulfide
storage temp.
2-8°C
SMILES string
S(Sc1ccncc1)c2ccncc2
InChI
1S/C10H8N2S2/c1-5-11-6-2-9(1)13-14-10-3-7-12-8-4-10/h1-8H
InChI key
UHBAPGWWRFVTFS-UHFFFAOYSA-N
Application
- Aldrithiol™-4 was used as cosubstrate in a study to develop highly specific inhibitors against mannose-binding lectin-associated serine proteases by in vitro evolution technology:phage display.
- It was used to study the O2 equilibria of recombinant human neuroglobin and cytoglobin measured under close to physiological conditions.
- It was used to modify gold surfaces for protein studies.
Legal Information
Aldrithiol is a trademark of Sigma-Aldrich Co. LLC
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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F Peter Guengerich et al.
Biochemistry, 42(37), 10965-10970 (2003-09-17)
The active site cysteine of human O(6)-alkylguanine-DNA alkyltransferase (hAGT), Cys145, was shown to be highly reactive with model electrophiles unrelated to substrates, including 1-chloro-2,4-dinitrobenzene. The high reactivity suggested that the Cys145 thiolate anion might be stable at neutral pH. The
Iveta Imriskova-Sosova et al.
Biochemistry, 44(51), 16949-16956 (2005-12-21)
Members of the Sco protein family are implicated in the assembly of the respiratory complex cytochrome c oxidase. Several possible roles have been proposed for Sco: a copper delivery agent, a site-specific thiol reductase, and an indicator of cellular redox
Soong-Yu Kuo et al.
Archives of toxicology, 77(11), 630-637 (2003-08-21)
The effect of oxidants on Ca(2+) movement in osteoblasts is unclear. In this study, we show that 4,4'-dithiodipyridine (4,4'-DTDP), a reactive disulphide that mobilizes Ca(2+) in muscle, induces an increase in cytoplasmic free-Ca(2+) concentrations ([Ca(2+)](i)) in MG63 human osteosarcoma cells