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Fórmula empírica (notación de Hill):
C50H78BF2N3O20P3
Número CAS:
Peso molecular:
1182.89
MDL number:
NACRES:
NA.25
UNSPSC Code:
12352211
Servicio técnico
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Permítanos ayudarleNombre del producto
TopFluor™ PI(4,5)P2, Avanti Research™ - A Croda Brand 810184P, powder
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 50 μg (with stopper and crimp cap (810184P-50ug))
manufacturer/tradename
Avanti Research™ - A Croda Brand 810184P
shipped in
dry ice
storage temp.
−20°C
General description
Although PI(4,5)P2 is a minor component of cell membranes, it plays a critical role as a substrate for a number of important signaling proteins. PI(4,5)P2 is an intermediate in the IP3/DAG pathway where it is hydrolyzed by phospholipase C to liberate the second messengers, inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). PI(4,5)P2 is also a substrate for PI 3-kinase where it is phosphorylated to PI(3,4,5)P3, an activator of downstream signaling components such as the protein kinase AKT.
Application
TopFluor™ PI(4,5)P2 or 1-oleoyl-2-{6-[4-(dipyrrometheneboron difluoride)butanoyl]amino}hexanoyl-sn-glycero-3-phosphoinositol-4,5-bisphosphate (ammonium salt) has been used as a fluorescent lipid in living cells to analyse the cellular localization of phosphatidylinositol (PI) and in the preparation of giant unilamellar vesicles (GUVs) for the ezrin-membrane tethering assays.
Packaging
2 mL Amber Serum Vial with Stopper and Crimp Cap (810184P-50ug)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
TopFluor is a trademark of Avanti Polar Lipids, LLC
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
No data available
flash_point_c
No data available
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Ezrin enrichment on curved membranes requires a specific conformation or interaction with a curvature-sensitive partner
Tsai FC, et al.
eLife, 7, e37262-e37262 (2018)
Feng-Ching Tsai et al.
eLife, 7 (2018-09-21)
One challenge in cell biology is to decipher the biophysical mechanisms governing protein enrichment on curved membranes and the resulting membrane deformation. The ERM protein ezrin is abundant and associated with cellular membranes that are flat, positively or negatively curved.
Probing the subcellular distribution of phosphatidylinositol reveals a surprising lack at the plasma membrane.
James PZ, et al.
The Journal of Cell Biology, 219(3), e201906127-e201906127 (2020)