SMC^® Human TNFα High Sensitivity Immunoassay Kit

Tumor necrosis factor-alpha (TNF-α) is a pro-inflammatory cytokine primarily produced by activated macrophages and T cells, playing a central role in the immune response. It is crucial for the regulation of inflammation, apoptosis, and the activation of other immune cells, facilitating the body′s defense against infections and tumors. However, excessive or dysregulated TNF-α production is associated with various inflammatory and autoimmune diseases, such as rheumatoid arthritis and Crohn′s disease, making it a significant target for therapeutic interventions.

Inflammatory Disease / Immune Response / Autoimmune Disease

96 well assay

• Sensitivity: LLOQ 200 fg/mL* (SMCxPRO^® Instrument)
• Standard Curve Range: 50-50,000 fg/mL
• Intra-assay CV: <15%
• Inter-assay CV: <20%
• Linearity: Serum: 113% Plasma: 105%
• Recovery: Serum: 95% Plasma: 83%

*Indicative LLOQ created from average of 14 independent in house runs, where >80% met same value defined with CV & Recovery +/- 20%. Refer to CoA for lot specific performance.

Although TNFα was detectable in non-human primate, rat, feline, canine and equine samples, the assay has not been verified for these species.

FEMTOQUEST is a trademark of Merck KGaA, Darmstadt, Germany

SMC is a registered trademark of Singulex

SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany

Our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.