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Merck

05-521

Anti-TRF2 Antibody, clone 4A794

clone 4A794, Upstate®, from mouse

Sinónimos:

Anti-TRBF2, Anti-TRF2

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UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
4A794, monoclonal
Application:
ICC, WB
Citations:
82

Documentos clave

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isotype

IgG1

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

4A794, monoclonal

species reactivity

rat, human

manufacturer/tradename

Upstate®

technique(s)

immunocytochemistry: suitable, western blot: suitable

NCBI accession no.

NM_005652

UniProt accession no.

Q15554

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... TERF2(7014)

General description

66 kDa
TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length. TRF2, like TRF1, contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localised to all human telomeres in metaphase chromosomes. TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini. The use of mutant forms of TRF2 has implicated a role for TRF2 in the prevention of senescence in primary human cells. Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types. TRF2 is overexpressed in a number of human tumors and overexpression of TRF2 has been shown to be oncogenic in a mouse model of carcinogenesis.

Immunogen

His-tagged, fusion-protein, corresponding to full-length TRF2 (Telomeric Repeat binding Factor 2), expressed in baculovirus

Application

Anti-TRF2 Antibody, clone 4A794 is a Mouse Monoclonal Antibody for detection of TRF2 also known as Telomeric repeat-binding factor 1 & has been tested in ICC & WB.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Cell Cycle, DNA Replication & Repair

Biochem/physiol Actions

Recognizes TRF2.

Physical form

Format: Purified
Protein G Purified
Protein G Purified mouse IgG1 in PBS with 0.05% sodium azide.

Preparation Note

Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Analysis Note

Control
Positive Antigen Control: Catalog #12-303, Jurkat cell lysate.
routinely evaluated by immunoblot on RIPA lysate of human Jurkat cells, HeLa nuclear extract, or rat L6 RIPA cell lysate

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Clase de almacenamiento

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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hnRNP A2, a potential ssDNA/RNA molecular adapter at the telomere.
Moran-Jones, K; Wayman, L; Kennedy, DD; Reddel, RR; Sara, S; Snee, MJ; Smith, R
Nucleic Acids Research null
S K Manna et al.
Journal of immunology (Baltimore, Md. : 1950), 165(9), 4927-4934 (2000-10-25)
We and others have reported that IFN-alpha potentiates the apoptotic effects of TNF through a mechanism that is not understood. Because the nuclear transcription factors NF-kappaB and AP-1 have recently been reported to mediate anti-apoptosis and cell survival, we hypothesized
Karolina O Hain et al.
Scientific reports, 6, 26766-26766 (2016-05-28)
A delay in the completion of metaphase induces a stress response that inhibits further cell proliferation or induces apoptosis. This response is thought to protect against genomic instability and is important for the effects of anti-mitotic cancer drugs. Here, we
Daniel H Lackner et al.
PloS one, 6(6), e21407-e21407 (2011-07-16)
Telomeres are nucleoprotein complexes which protect the ends of linear chromosomes from detection as DNA damage and provide a sequence buffer against replication-associated shortening. In mammals, telomeres consist of repetitive DNA sequence (TTAGGG) and associated proteins. The telomeric core complex
Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II.
Stefan Schoeftner, Maria A Blasco, Stefan Schoeftner, Maria A Blasco
Nature Cell Biology null
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