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Merck

07-326

Anti-phospho-Cofilin 2 (Ser3) Antibody

Upstate®, from rabbit

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UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
polyclonal
Species reactivity:
mouse, chicken, human
Application:
WB
Citations:
11
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biological source

rabbit

Quality Level

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

species reactivity

mouse, chicken, human

manufacturer/tradename

Upstate®

technique(s)

western blot: suitable

isotype

IgG

NCBI accession no.

UniProt accession no.

shipped in

dry ice

target post-translational modification

phosphorylation (pSer3)

Gene Information

human ... CFL2(1073)

General description

21kDa

Immunogen

peptide corresponding to amino acids 1-10 (MA[pS]GVTVNDE-C) of human phospho-Cofilin 2

Application

Anti-phospho-Cofilin 2 (Ser3) Antibody detects level of phospho-Cofilin 2 (Ser3) & has been published & validated for use in WB.
Research Category
Cell Structure
Research Sub Category
Cytoskeleton

Biochem/physiol Actions

phospho-Cofilin 2

Physical form

0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Format: Purified
Protein A chromatography

Preparation Note

2 years at -20°C

Analysis Note

routinely evaluated by immunoblot on RIPA lysates from L6 cells, treated with LIM Kinase

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.


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Clase de almacenamiento

10 - Combustible liquids

wgk

WGK 1



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Toru Amano et al.
The Journal of biological chemistry, 277(24), 22093-22102 (2002-04-02)
Actin filament dynamics play a critical role in mitosis and cytokinesis. LIM motif-containing protein kinase 1 (LIMK1) regulates actin reorganization by phosphorylating and inactivating cofilin, an actin-depolymerizing and -severing protein. To examine the role of LIMK1 and cofilin during the
C Thirion et al.
European journal of biochemistry, 268(12), 3473-3482 (2001-06-26)
Cofilins are actin binding proteins and regulate actin assembly in vivo. Numerous cofilin homologues have been characterized in various organisms including mammals. In mice, a ubiquitously expressed cofilin (CFL1) and a skeletal muscle specific cofilin (CFL2) have been described. In
Mardjaneh Sadegh Karbalaei et al.
European journal of pharmacology, 689(1-3), 179-185 (2012-05-31)
Caveolae are membrane invaginations present in a variety of cell types. Formation of caveolae depends on caveolins and on the more recently discovered family of proteins known as the cavins. Genetic ablation of caveolin-1 was previously shown to give rise



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SKUGTIN
07-32604053252369612