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Merck

19-135

p38/SAPK2 Inhibitor (SB 203580)

The p38/SAPK2 Inhibitor (SB 203580) controls the biological activity of p38/SAPK2. This small molecule/inhibitor is primarily used for Biochemicals applications.

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UNSPSC Code:
12352200
NACRES:
NA.41
eCl@ss:
32160405

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Nombre del producto

p38/SAPK2 Inhibitor (SB 203580), The p38/SAPK2 Inhibitor (SB 203580) controls the biological activity of p38/SAPK2. This small molecule/inhibitor is primarily used for Biochemicals applications.

form

solid

manufacturer/tradename

Upstate®

technique(s)

activity assay: suitable (kinase)

NCBI accession no.

NM_002751.5

UniProt accession no.

Q15759

shipped in

wet ice

Quality Level

100

Analysis Note

Routinely evaluated in a kinase assay.

Application

Highly specific inhibitor of p38/SAPK2

Biochem/physiol Actions

Inhibitor Type: Kinase
Protein Target: p38/SAPK2
Target Sub-Family: CMGC

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Physical form

C12H16FN3OS

Preparation Note

3 years at -20°C

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Clase de almacenamiento

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function.
Badger, A M, et al.
Journal of Pharmacology and Experimental Therapeutics, 279, 1453-1461 (1996)
p38/RK is essential for stress-induced nuclear responses: JNK/SAPKs and c-Jun/ATF-2 phosphorylation are insufficient.
Hazzalin, C A, et al.
Current Biology, 6, 1028-1031 (1996)
J Saklatvala et al.
The Journal of biological chemistry, 271(12), 6586-6589 (1996-03-22)
p38 mitogen-activated protein kinase (MAPK) was identified in platelets on the basis of (a) its reactivity with antibodies to C-terminal and N-terminal peptides, and (b) its ability to activate MAPK-activated protein kinase-2, which phosphorylates the small heat shock protein, hsp27.
Liangxuan Zhang et al.
Infection and immunity, 72(1), 38-45 (2003-12-23)
Our previous studies showed that bacterial heat shock protein 60 (hsp60) induces cultured epithelial cell proliferation within 24 h. Here we investigated the long-term effects of heat shock protein 60 isolated from Actinobacillus actinomycetemcomitans on skin keratinocyte (HaCaT cell line)
R M Kramer et al.
The Journal of biological chemistry, 271(44), 27723-27729 (1996-11-01)
The Ca2+-sensitive 85-kDa cytosolic phospholipase A2 (cPLA2) is responsible for thrombin-stimulated mobilization of arachidonic acid for the synthesis of thromboxane A2 in human platelets. We have previously shown that thrombin activates p38 kinase, a recently discovered new member of the
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