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Merck

341205

Etoposide

≥95% (HPLC), solid, topoisomerase II inhibitor, Calbiochem

Sinónimos:

Etoposide, VP-16

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Fórmula empírica (notación de Hill):
C29H32O13
Número CAS:
33419-42-0
Peso molecular:
588.56
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00869325

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Nombre del producto

Etoposide, A cell-permeable derivative of podophyllotoxin that acts as a topoisomerase II inhibitor (IC50 = 59.2 µM) has major activity against a number of tumors, including germ cell neoplasms, small cell lung cancer, and malignant lymphoma.

SMILES string

O1[C@@H]2[C@H](O[C@H]([C@@H]([C@H]2O)O)O[C@H]3[C@@H]4[C@@H]([C@@H](c6c3cc7c(c6)OCO7)c5cc(c(c(c5)OC)O)OC)C(=O)OC4)CO[C@H]1C

InChI

1S/C29H32O13/c1-11-36-9-20-27(40-11)24(31)25(32)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)23(30)19(5-12)35-3/h4-7,11,15,20-22,24-27,29-32H,8-10H2,1-3H3/t11-,15+,20-,21-,22+,24-,25-,26-,27-,29+/m1/s1

InChI key

VJJPUSNTGOMMGY-MRVIYFEKSA-N

description

Merck USA index - 14, 3886

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

white

solubility

DMSO: 25 mg/mL

shipped in

ambient

storage temp.

10-30°C

Quality Level

100

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General description

A cell-permeable, topoisomerase II inhibitor (IC50 = 59.2 µM). A derivative of podophyllotoxin (Cat. No. 540040) that has major activity against a number of tumors, including germ cell neoplasms, small cell lung cancer, and malignant lymphoma. Induces apoptosis in mouse thymocytes and in HL-60 human leukemia cells.
A cell-permeable derivative of podophyllotoxin that acts as a topoisomerase II inhibitor (IC50 = 59.2 µM) has major activity against a number of tumors, including germ cell neoplasms, small cell lung cancer, and malignant lymphoma. Induces apoptosis in mouse thymocytes and in HL-60 human leukemia cells.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
topoisomerase 2
Product does not compete with ATP.
Reversible: no
Target IC50: 59.2 µM inhibiting topoisomerase II

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

De Lange, A.M., et al. 1995. J. Virol. 69, 2082.
Kaufman, S.H., et al. 1993. Cancer Res.53, 3976.
Onishi, Y., et al. 1993. Biochim. Biophys. Acta1175, 147.
Terada, T., et al. 1993. J. Med. Chem. 36, 1689.
Wazniak, A.J., et al. 1991. J. Clin. Oncol.9, 70.
Einhorn, L.H., et al. 1988. J. Clin. Oncol.6, 451.
Issel, B.F. 1982. Cancer Chemother. Pharmacol.7, 73.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 1B - Repr. 2

Clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

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