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Merck

572630

SU-5402

≥95% (HPLC), lyophilized solid, FGFR1 inhibitor, Calbiochem

Sinónimos:

SU5402, 3-[3-(2-Carboxyethyl)-4-methylpyrrol-2-methylidenyl]-2-indolinone

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About This Item

Fórmula empírica (notación de Hill):
C17H16N2O3
Número CAS:
215543-92-3
Peso molecular:
296.32
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD08235144

Nombre del producto

SU5402, SU5402, CAS 215543-92-3, is a cell-permeable, reversible, and ATP-competitive inhibitor of the tyrosine kinase activity of FGFR1 (IC50 = 10-20 µM in the presence of 1 mM ATP).

SMILES string

[nH]1c(c(c(c1)C)CCC(=O)O)\C=C2\c3c(cccc3)NC\2=O

InChI

1S/C17H16N2O3/c1-10-9-18-15(11(10)6-7-16(20)21)8-13-12-4-2-3-5-14(12)19-17(13)22/h2-5,8-9,18H,6-7H2,1H3,(H,19,22)(H,20,21)/b13-8-

InChI key

JNDVEAXZWJIOKB-JYRVWZFOSA-N

assay

≥95% (HPLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

solubility

DMSO: 25 mg/mL

shipped in

ambient

Quality Level

200

storage temp.

2-8°C

Categorías relacionadas

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Fibroblast growth factor receptor 1 (FGFR1)
Product competes with ATP.
Reversible: yes
Target IC50: 10-20 &10-20 µM for fibroblast growth factor receptor 1 (FGFR1) in the presence of 1 mM ATP;M against FGFR1 in the presence of 1 mM ATP; 10-20 µM against inhibits aFGF-induced tyrosine phosphorylation of ERK1 and ERK2

Disclaimer

Toxicity: Standard Handling (A)

General description

A cell-permeable, reversible, and ATP-competitive inhibitor of the tyrosine kinase activity of fibroblast growth factor receptor 1 (FGFR1; IC50 = 10-20 µM in the presence of 1 mM ATP). Also inhibits aFGF-induced tyrosine phosphorylation of ERK1 and ERK2 (IC50 = 10-20 µM). In contrast to SU4984 (Cat. No. 572625), SU5402 is only a weak inhibitor of tyrosine phosphorylation of the PDGF receptor and does not inhibit phosphorylation of the insulin receptor. Does not inhibit the kinase activity of the EGF receptor. A 10 mM (500 µg/169 µl) solution of SU5402 (Cat. No. 572631) in DMSO is also available.

Legal Information

Not available for sale in the United States.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Mohammadi, M., et al. 1997. Science 276, 955.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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