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Merck

OP39

Anti-c-ErbB2/c-Neu (Ab-5) Mouse mAb (TA-1)

liquid, clone TA-1, Calbiochem®

Sinónimos:

Anti-HER2, Anti-c-Neu, Anti-ErbB2, Anti-Erythroblastosis Virus

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NACRES:
NA.43
UNSPSC Code:
12352203
Clone:
TA-1, monoclonal
Species reactivity:
human
Application:
—
Citations:
3

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biological source

mouse

antibody form

purified antibody

antibody product type

primary antibodies

clone

TA-1, monoclonal

form

liquid

contains

≤0.1% sodium azide as preservative

species reactivity

human

should not react with

mouse, rat

manufacturer/tradename

Calbiochem®

storage condition

do not freeze

dilution

(Flow Cytometry (5 µg/mL,
Frozen Sections (5 µg/mL)
Immunoblotting
Immunofluorescence (5 µg/mL,
Immunoprecipitation (1 µg/sample,
Neutralization Studies (not recommended and application references))

isotype

IgG1

shipped in

wet ice

Quality Level

100

Gene Information

human ... ERBB2(2064)

target post-translational modification

unmodified

Categorías relacionadas

General description

Anti-c-ErbB2/c-Neu (Ab-5), mouse monoclonal, clone TA-, recognizes the ~185 kDa c-ErbB2/c-Neu protein in SK-BR-3 cells. It is validated for FC, WB, IF, IP, and IHC on frozen sections.
Purified mouse monoclonal antibody generated by immunizing BALB/c mice with the specified immunogen and fusing spleonocytes with SP2/0 mouse myeloma cells (see application references). Recognizes the c-ErbB2/c-neu protein.
Recognizes the ~185 kDa c-ErbB2/c-Neu protein in SK-BR-3 cells.

Application

Flow Cytometry (5 µg/ml, see application references)

Frozen Sections (5 µg/ml)

Immunoblotting (see application references)

Immunofluorescence (5 µg/ml, see application references)

Immunoprecipitation (1 µg/sample, see application references)

Neutralization Studies (not recommended, see comments and application references)

Packaging

Please refer to vial label for lot-specific concentration.

Physical form

In 50 mM PBS, 0.2% gelatin, pH 7.5.

Analysis Note

Positive Control
SK-BR-3 cells

Other Notes

DiFiore, P.P., et al. 1987. Science237, 178.
Slamon, D.J., et al. 1987. Science235, 177.
Varley, J.M., et al. 1987. Oncogene1, 423.
Yamamoto, T., et al. 1986. Nature319, 230.
Blick, M., et al. 1984. Blood64, 1234.
Schwab, M., et al. 1984 Cold Spring Harbor Laboratory2, 215.
Bargmann, C.I., et al. 1968. Nature319, 226.
Recognizes an extracellular epitope and does not cross react with human EGF-receptor. It will not inhibit in vivo protein tyrosine kinase activity. Antibody should be titrated for optimal results in individual systems.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Heather Gibson et al.
Oncoimmunology, 4(1), e984523-e984523 (2015-05-08)
The goal is to elucidate the immune modulating activity of an adenovirus (Adv) vector which showed therapeutic activity in human clinical trials. The oncolytic adenovirus (Adv/CD-TK) expressing two suicide genes was tested in two HER2/neu positive BALB/c mouse mammary tumor
Vineesh Indira Chandran et al.
Molecular cancer research : MCR, 18(4), 644-656 (2020-01-05)
The antibody-drug conjugate trastuzumab-emtansine (T-DM1) offers an additional treatment option for patients with HER2-amplified tumors. However, primary and acquired resistance is a limiting factor in a significant subset of patients. Hypoxia, a hallmark of cancer, regulates the trafficking of several
Min Gyu Jeong et al.
Experimental & molecular medicine, 53(2), 291-299 (2021-02-20)
Various repertoires of membrane protein interactions determine cellular responses to diverse environments around cells dynamically in space and time. Current assays, however, have limitations in unraveling these interactions in the physiological states in a living cell due to the lack

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