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Fórmula empírica (notación de Hill):
C21H25NO5
Número CAS:
Peso molecular:
371.43
PubChem Substance ID:
UNSPSC Code:
12352207
Beilstein/REAXYS Number:
2822892
MDL number:
NACRES:
NA.54
Form:
solution
Quality level:
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Permítanos ayudarleNombre del producto
Colcemid, solution, suitable for blocking, sterile; 0.2 μm filtered
SMILES string
CN[C@H]1CCc2cc(OC)c(OC)c(OC)c2C3=CC=C(OC)C(=O)C=C13
InChI
1S/C21H25NO5/c1-22-15-8-6-12-10-18(25-3)20(26-4)21(27-5)19(12)13-7-9-17(24-2)16(23)11-14(13)15/h7,9-11,15,22H,6,8H2,1-5H3/t15-/m0/s1
InChI key
NNJPGOLRFBJNIW-HNNXBMFYSA-N
description
N-methyl-N-deacetyl-colchicine
sterility
sterile; 0.2 μm filtered
form
solution
packaging
pkg of 20 mL (10 μg/ml)
manufacturer/tradename
Roche
technique(s)
blocking: suitable
impurities
microbial, tested
solubility
water: miscible
storage temp.
2-8°C
Quality Level
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Application
Colcemid inhibits the formation of mitotic spindles. It is used to increase the percentage of metaphase cells for chromosome analysis.
Biochem/physiol Actions
Often in karyotyping and cell cycle research it is desirable to increase the yield of mitotic cells in a particular phase of the cell cycle. This can be achieved in a variety of ways with the most popular being the use of a cell cycle synchronizing agent such as demecolcine. Demecolcine will arrest cells in metaphase with no remarkable effect on the biochemical events in mitotic cells or in synchronized G1 and S phase cells. White blood cells are often treated with demecolcine to arrest cells in metaphase.
General description
Colcemid is also known as demecolcine. Its generic name is N-methyl-N-deacetyl-colchicine. Colcemid depolymerizes microtubules and blocks mitosis at metaphase.
Other Notes
For life science research only. Not for use in diagnostic procedures.
Physical form
Solution (10 μg/ml), filtered through 0.2 μm pore size membrane.
Clase de almacenamiento
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
does not flash
flash_point_c
does not flash
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