Aptamers are short RNA or DNA oligonucleotides which can bind with different targets. Typically, they are selected from a large number of random DNA sequence libraries. The main strategy to obtain aptamers is systematic evolution of ligands by exponential enrichment

Regulation of autoimmune arthritis by the pro-inflammatory cytokine interferon-gamma.

Eugene Y Kim et al.

Clinical immunology (Orlando, Fla.), 127(1), 98-106 (2008-02-16)

The pathogenesis of T cell-mediated diseases like rheumatoid arthritis (RA) has typically been explained in the context of the Th1-Th2 paradigm: the initiation/propagation by pro-inflammatory cytokines, and downregulation by Th2 cytokines. However, in our study based on the adjuvant-induced arthritis

gammaCOP is required for apical protein secretion and epithelial morphogenesis in Drosophila melanogaster.

Nicole C Grieder et al.

PloS one, 3(9), e3241-e3241 (2008-09-20)

There is increasing evidence that tissue-specific modifications of basic cellular functions play an important role in development and disease. To identify the functions of COPI coatomer-mediated membrane trafficking in Drosophila development, we were aiming to create loss-of-function mutations in the

Abnormal fluid homeostasis in apelin receptor knockout mice.

Emma M Roberts et al.

The Journal of endocrinology, 202(3), 453-462 (2009-07-07)

The apelinergic system, comprised of apelin and its G protein-coupled receptor (APJ; APLNR as given in MGI Database), is expressed within key regions of the central nervous system associated with arginine vasopressin (AVP) synthesis and release as well as in

In vivo growth of Pseudomonas aeruginosa strains PAO1 and PA14 and the hypervirulent strain LESB58 in a rat model of chronic lung infection.

Irena Kukavica-Ibrulj et al.

Journal of bacteriology, 190(8), 2804-2813 (2007-12-18)

Pseudomonas aeruginosa chronic lung infections are the major cause of morbidity and mortality in cystic fibrosis (CF) patients. The P. aeruginosa strains PAO1 and PA14 were compared with the Liverpool epidemic strain LESB58 to assess in vivo growth, infection kinetics

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