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Merck

PHR1003

Aspirin (Acetyl Salicylic Acid)

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

Acetylsalicylic acid, 2-Acetoxybenzoic acid, O-Acetylsalicylic acid, ASA, Aspirin

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Fórmula lineal:
2-(CH3CO2)C6H4CO2H
Número CAS:
50-78-2
Peso molecular:
180.16
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823034
EC Number:
200-064-1
Beilstein/REAXYS Number:
779271
MDL number:
MFCD00002430

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Nombre del producto

Aspirin (Acetyl Salicylic Acid), Pharmaceutical Secondary Standard; Certified Reference Material

InChI key

BSYNRYMUTXBXSQ-UHFFFAOYSA-N

InChI

1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)

SMILES string

CC(=O)Oc1ccccc1C(O)=O

grade

certified reference material
pharmaceutical secondary standard

agency

USP 1044006
traceable to Ph. Eur. A0200000

API family

aspirin

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

134-136 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

Gene Information

human ... PTGS1(5742), PTGS2(5743)

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Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Application

Aspirin (Acetyl Salicylic Acid) may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using spectrophotometric technique and reversed-phase high-performance liquid chromatography technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Blocks the production of prostaglandins by inhibiting cyclooxygenase (prostaglandin H synthase), with greater selectivity toward the COX-1 isoform. The antithrombotic effect is due to the inhibition of COX-1 in platelets that blocks thromboxane production and platelet aggregation. Chemopreventive against colorectal and other solid tumors.
Blocks the production of prostaglandins by inhibiting cyclooxygenase (prostaglandin H synthase), with greater selectivity toward the COX-1 isoform. The antithrombotic effect is due to the inhibition of COX-1 in platelets that blocks thromboxane production and platelet aggregation. Chemopreventive against colorectal and other solid tumors.

General description

Aspirin (Acetyl Salicylic Acid) is a cyclo-oxygenase inhibitor and an antiplatelet agent, widely used for the secondary preventions of heart attack and stroke.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAB7669 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 1

flash_point_f

482.0 °F

flash_point_c

250 °C

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Preliminary studies on the analgesic activity of latex of Calotropris procera
Dewan.S, et al.
Journal of Ethnopharmacology, 73, 307-311 (2000)
Studies on the anti-inflammatory and analgesic activity of Cedrus deodara (Roxb.) Loud. wood oil
Shinde.AU, et al.
Journal of Ethnopharmacology, 65, 21-27 (1999)
Simultaneous determination of clopidogrel and aspirin in pharmaceutical dosage forms
Mishra P and Dolly A
Indian Journal of Pharmaceutical Sciences, 63(3) (2006)
Rapid and simultaneous determination of aspirin and dipyridamole in pharmaceutical formulations by reversed-phase high performance liquid chromatography (RP-HPLC) method
Prakash K, et al.
African Journal of Pharmacy and Pharmacology, 5(2), 244-251 (2011)
A O Maree et al.
Journal of thrombosis and haemostasis : JTH, 3(10), 2340-2345 (2005-09-10)
Aspirin (acetylsalicylic acid) irreversibly inhibits platelet cyclooxygenase (COX)-1, the enzyme that converts arachidonic acid (AA) to the potent platelet agonist thromboxane (TX) A2. Despite clear benefit from aspirin in patients with cardiovascular disease (CAD), evidence of heterogeneity in the way
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