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Merck

PHR1015

Diphenhydramine hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

DP, DPH, 2-Diphenylmethoxy-N,N-dimethylethylamine hydrochloride, N-(2-Diphenylmethoxyethyl)-N,N-dimethylamine hydrochloride

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Fórmula empírica (notación de Hill):
C17H21NO · HCl
Número CAS:
147-24-0
Peso molecular:
291.82
NACRES:
NA.24
PubChem Substance ID:
329823046
UNSPSC Code:
41116107
EC Number:
205-687-2
MDL number:
MFCD00012479

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InChI key

PCHPORCSPXIHLZ-UHFFFAOYSA-N

InChI

1S/C17H21NO.ClH/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;/h3-12,17H,13-14H2,1-2H3;1H

SMILES string

Cl[H].CN(C)CCOC(c1ccccc1)c2ccccc2

grade

certified reference material, pharmaceutical secondary standard

agency

USP 1218005, traceable to Ph. Eur. D2000000

API family

diphenhydramine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

Gene Information

human ... HRH1(3269)

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Diphenhydramine hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

To see an example of a Certificate of Analysis for this material enter LRAB7790 in the slot below. This is an example certificate only and may not be the lot that you receive.
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Clase de almacenamiento

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Quantitative analysis of liquid formulations using FT-Raman spectroscopy and HPLC: The case of diphenhydramine hydrochloride in [TM="Benadryl"]
Orkoula MG, et al.
Journal of Pharmaceutical and Biomedical Analysis, 41(4), 1406-1411 (2006)
Optimization and validation of a method for the determination of caffeine, 8-chlorotheophylline and diphenhydramine by isocratic high-performance liquid chromatography: Stress test for stability evaluation
Barbas C, et al.
Journal of Chromatography A, 870(1), 97-103 (2000)
Development and validation of a capillary electrophoresis method for the determination of codeine, diphenhydramine, ephedrine and noscapine in pharmaceuticals
Gomez MR, et al.
Il Farmaco (Societa Chimica Italiana : 1989), 60(1), 85-90 (2005)
Analysis of pharmaceutical preparations containing antihistamine drugs by micellar liquid chromatography
Martinez-Algaba C, et al.
Journal of Pharmaceutical and Biomedical Analysis, 40(2), 312-321 (2006)
Manoj Reddy Medapati et al.
International journal of molecular sciences, 22(18) (2021-09-29)
Bitter-taste receptors (T2Rs) have emerged as key players in host-pathogen interactions and important modulators of oral innate immunity. Previously, we reported that T2R14 is expressed in gingival epithelial cells (GECs) and interacts with competence stimulating peptides (CSPs) secreted by the
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