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Merck

PHR1317

Tolueno

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

Toluene

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Fórmula lineal:
C6H5CH3
Número CAS:
Peso molecular:
92.14
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
203-625-9
Beilstein/REAXYS Number:
635760
MDL number:
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InChI key

YXFVVABEGXRONW-UHFFFAOYSA-N

InChI

1S/C7H8/c1-7-5-3-2-4-6-7/h2-6H,1H3

SMILES string

Cc1ccccc1

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to USP 1601805

vapor density

3.2 (vs air)

vapor pressure

22 mmHg ( 20 °C), 26 mmHg ( 25 °C)

CofA

current certificate can be downloaded

autoignition temp.

997 °F

expl. lim.

7 %

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

refractive index

n/D 1.496 (lit.)

bp

110-111 °C (lit.)

mp

-93 °C (lit.)

density

0.865 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

single component solution

storage temp.

2-30°C

Quality Level

Categorías relacionadas

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Residual Solvent – Toluene is a certified reference material for the screening and quantification of residual solvents. This CRM is a secondary pharmaceutical reference standard and is traceable and qualified against the corresponding pharmacopeial standards.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC1709 in the slot below. This is an example certificate only and may not be the lot that you receive.

signalword

Danger

Hazard Classifications

Aquatic Chronic 3 - Asp. Tox. 1 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 2 Inhalation - STOT SE 3

target_organs

Central nervous system

Clase de almacenamiento

3 - Flammable liquids

wgk

WGK 3

flash_point_f

39.9 °F - closed cup

flash_point_c

4.4 °C - closed cup


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Murat Yücel et al.
Neuroscience and biobehavioral reviews, 32(5), 910-926 (2008-05-06)
Organic solvent abuse is associated with increased risk for serious medical, neurological, and neuropsychological impairments. While animal research suggests that exposure to organic solvents (especially toluene) may be neurotoxic, much less is known about the consequences of long-term exposure in
Elke Persch et al.
ChemMedChem, 9(8), 1880-1891 (2014-05-03)
The causative agents of the parasitic disease human African trypanosomiasis belong to the family of trypanosomatids. These parasitic protozoa exhibit a unique thiol redox metabolism that is based on the flavoenzyme trypanothione reductase (TR). TR was identified as a potential
Christopher M Filley et al.
Journal of neuropathology and experimental neurology, 63(1), 1-12 (2004-01-30)
In recent decades the organic solvent toluene (methylbenzene) has emerged as one of the best-studied neurotoxins. Long-term and intense exposure to toluene vapors in humans who abuse spray paint and related substances has led to the recognition that toluene has
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Faraday discussions, 173, 287-296 (2014-12-04)
The photoinduced reactive oxygen species (ROS) generation from several water-soluble fullerenes was examined. Macromolecular or small molecular water-soluble fullerene complexes/derivatives were prepared and their (1)O(2) and O(2)˙(-) generation abilities were evaluated by ESR spin-trapping methods. As a result, efficient (1)O(2)
Perrine Hoet et al.
Critical reviews in toxicology, 38(2), 127-170 (2008-02-09)
Noise is the most common preventable cause of irreversible sensorineural hearing loss. During recent years, the results of experimental and human investigations have raised the level of concern about the potential ototoxicity of chemical agents and their interaction with noise.

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