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Merck

PHR1500

Imidurea

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

Imidazolidinyl urea, N,N′′-Methylenebis[N′-[3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-urea

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Fórmula empírica (notación de Hill):
C11H16N8O8
Número CAS:
39236-46-9
Peso molecular:
388.29
NACRES:
NA.24
PubChem Substance ID:
329823421
UNSPSC Code:
41116107
EC Number:
254-372-6
MDL number:
MFCD00221482

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InChI key

ZCTXEAQXZGPWFG-UHFFFAOYSA-N

InChI

1S/C11H16N8O8/c20-2-18-4(6(22)16-10(18)26)14-8(24)12-1-13-9(25)15-5-7(23)17-11(27)19(5)3-21/h4-5,20-21H,1-3H2,(H2,12,14,24)(H2,13,15,25)(H,16,22,26)(H,17,23,27)

SMILES string

OCN1C(NC(=O)NCNC(=O)NC2N(CO)C(=O)NC2=O)C(=O)NC1=O

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to USP 1336806

API family

imidurea

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Imidurea may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Used in:
Pharmacological studies investigating nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis
Therapeutic studies involving nanostructured vegetable-based carriers for topical delivery of active molecules
Topical formulas for use as antioxidants

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA3048 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H317

pcodes

P280

Hazard Classifications

Skin Sens. 1B

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Analysis of preservative in pharmaceutical products
Fahelelbom KMS, et al.
Pharmaceutical Reviews, 5(1), 3960-3968 (2007)
Validation of a micellar electrokinetic capillary chromatography method for the determination of imidurea, methyl and propylparabens in a pharmaceutical ointment
Baalbaki B, et al.
Analytica Chimica Acta, 463(1), 15-20 (2002)
María Castro-Puyana et al.
Electrophoresis, 26(20), 3960-3968 (2005-10-12)
EKC using a neutral CD as chiral selector was applied in this work to the development of a method enabling the enantiomeric separation of ketoconazole and terconazole antifungals. The influence of different experimental conditions such as temperature, CD concentration, pH

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