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Merck

Y0001404

Vigabatrin impurity D

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

γ-Aminobutyric acid, 3-Carboxypropylamine, 4-Aminobutanoic acid, GABA, Piperidic acid, Piperidinic acid

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Fórmula lineal:
NH2(CH2)3COOH
Número CAS:
Peso molecular:
103.12
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
906818
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grade

pharmaceutical primary standard

API family

vigabatrin

manufacturer/tradename

EDQM

mp

195 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

NCCCC(O)=O

InChI

1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)

InChI key

BTCSSZJGUNDROE-UHFFFAOYSA-N

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Vigabatrin impurity D EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Major inhibitory neurotransmitter in brain; GABAA and GABAB receptor agonist; increases Cl conductance.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.


Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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Hussein A N Al-Wadei et al.
Molecular nutrition & food research, 55(12), 1745-1758 (2011-08-02)
GABA is a bioactive constituent of fruits, vegetables, cereals and is believed to play a role in defense against stress in plants. In animals, it acts as an inhibitory neurotransmitter in brain while also expressed in non-neuronal cells. Studies have
Jesse Jackson et al.
Nature neuroscience, 17(10), 1362-1370 (2014-09-01)
Activity flow through the hippocampus is thought to arise exclusively from unidirectional excitatory synaptic signaling from CA3 to CA1 to the subiculum. Theta rhythms are important for hippocampal synchronization during episodic memory processing; thus, it is assumed that theta rhythms
Melissa A Farmer et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(17), 5747-5753 (2014-04-25)
Chronic pain is often associated with sexual dysfunction, suggesting that pain can reduce libido. We find that inflammatory pain reduces sexual motivation, measured via mounting behavior and/or proximity in a paced mating paradigm, in female but not male laboratory mice.