Timidina

Name: Timidina
Brand: SIGMA

≥99.0% (HPLC), synthetic, powder

Sinónimos:

1-(2-desoxi-β-D-ribofuranosil)-5-metiluracilo, 1-(2-desoxi-β-D-ribofuranosil)timina, 2′-desoxitimidina, Desoxirribósido de timina, dT

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About This Item

Fórmula empírica (notación de Hill):

C₁₀H₁₄N₂O₅

Número CAS:

50-89-5

Peso molecular:

242.23

NACRES:

NA.51

PubChem Substance ID:

329769717

UNSPSC Code:

41106305

EC Number:

200-070-4

MDL number:

MFCD00006537

Beilstein/REAXYS Number:

89285

Nombre del producto

Timidina, ≥99.0% (HPLC)

InChI key

IQFYYKKMVGJFEH-XLPZGREQSA-N

InChI

1S/C10H14N2O5/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16)/t6-,7+,8+/m0/s1

SMILES string

CC1=CN([C@H]2C[C@H](O)[C@@H](CO)O2)C(=O)NC1=O

biological source

synthetic

assay

≥99.0% (HPLC)

form

powder

optical activity

[α]20/D +19±1°, c = 1% in H₂O

mp

185-190 °C
186-188 °C (lit.)

solubility

hot water: 1 g/10 mL

Quality Level

200

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Categorías relacionadas

Nucleósidos y nucleótidos

Application

Thymidine has been used:

to culture human fibroblast cell lines.
in in vitro wound healing assay.
to culture various cancer cell lines.

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Edward J Gane et al.

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There is a close relationship between chronic hepatitis B virus infection and chronic renal disease. We analyzed changes in renal function using different markers of glomerular filtration rate (GFR) in multiple studies of telbivudine treatment of patients with chronic hepatitis

The impact of induction therapy on the homeostasis and function of regulatory T cells in kidney transplant patients.

Anne P Bouvy et al.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 29(8), 1587-1597 (2014-04-29)

To evaluate the influence of induction therapy on Tregs we investigated their origin, kinetics and function in kidney transplant patients after treatment with T-cell depleting rabbit antithymocyte globulin (rATG) or IL-2 receptor antagonist basiliximab. Flow cytometry was used to study

Multiple immune factors are involved in controlling acute and chronic chikungunya virus infection.

Yee Suan Poo et al.

PLoS neglected tropical diseases, 8(12), e3354-e3354 (2014-12-05)

The recent epidemic of the arthritogenic alphavirus, chikungunya virus (CHIKV) has prompted a quest to understand the correlates of protection against virus and disease in order to inform development of new interventions. Herein we highlight the propensity of CHIKV infections

Identification and biochemical characterization of an acid sphingomyelinase-like protein from the bacterial plant pathogen Ralstonia solanacearum that hydrolyzes ATP to AMP but not sphingomyelin to ceramide.

Michael V Airola et al.

PloS one, 9(8), e105830-e105830 (2014-08-22)

Acid sphingomyelinase (aSMase) is a human enzyme that catalyzes the hydrolysis of sphingomyelin to generate the bioactive lipid ceramide and phosphocholine. ASMase deficiency is the underlying cause of the genetic diseases Niemann-Pick Type A and B and has been implicated

Spatial regulation of Aurora A activity during mitotic spindle assembly requires RHAMM to correctly localize TPX2.

Helen Chen et al.

Cell cycle (Georgetown, Tex.), 13(14), 2248-2261 (2014-05-31)

Construction of a mitotic spindle requires biochemical pathways to assemble spindle microtubules and structural proteins to organize these microtubules into a bipolar array. Through a complex with dynein, the receptor for hyaluronan-mediated motility (RHAMM) cross-links mitotic microtubules to provide structural

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