A0638
Adipic acid dihydrazide
≥98% (titration)
Sinónimos:
Hexanedihydrazide
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About This Item
Fórmula lineal:
NH2NHCO(CH2)4CONHNH2
Número CAS:
Peso molecular:
174.20
UNSPSC Code:
12352127
NACRES:
NA.25
PubChem Substance ID:
EC Number:
213-999-5
Beilstein/REAXYS Number:
973863
MDL number:
Nombre del producto
Adipic acid dihydrazide, ≥98% (titration)
InChI key
IBVAQQYNSHJXBV-UHFFFAOYSA-N
InChI
1S/C6H14N4O2/c7-9-5(11)3-1-2-4-6(12)10-8/h1-4,7-8H2,(H,9,11)(H,10,12)
SMILES string
NNC(=O)CCCCC(=O)NN
assay
≥98% (titration)
form
powder
reaction suitability
reagent type: cross-linking reagent
mp
180-182 °C (lit.)
solubility
H2O: 100 mg/mL
storage temp.
−20°C
Quality Level
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Application
Adipic acid dihydrazide has been used:
- in the preparation of reactive premix to synthesize the porous biomaterial
- for the crosslinking of methacrylated chondroitin sulfate (MA-CS) coating using carbodiimide-based chemistry for the production and characterization of methacrylated chondroitin sulfate magnetic nanoparticles (MA-CS MNPs)
- for the covalent labeling of rhamnolipids, pyochelin, and vancomycin with Abberior STARNHS ester dye
Biochem/physiol Actions
Adipic acid dihydrazide (ADH) is a low molecular weight compound that comprises a hydrazide group at each end. This leads to the supply of extra adsorption sites for heavy metals that maintain or elevate the adsorption capacities of the cross-linked adsorbents. ADH is used as a crosslinker in various fields, like making mechanical latexes films and injectable oxidized hyaluronic acid hydrogel.
General description
Adipic acid dihydrazide is a homobifunctional cross-linking reagent that is specific for aldehydes. This results in relatively stable hydrazone linkages. Adipic acid dihydrazide is generally used in the linking of glycoproteins, like antibodies, in a site-specific fashion following periodate oxidation. Oxidation and coupling may be performed at pH 5.0 due to the low pKa of the hydrazide which avoids competition by primary amines.
Other Notes
Note that the hydrazone bond may be stabilized by selective reduction using, for example, sodium cyanoborohydride.
hcodes
pcodes
Hazard Classifications
Aquatic Chronic 2
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
302.0 °F - closed cup
flash_point_c
150 °C - closed cup
ppe
Eyeshields, Gloves, type N95 (US)
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Bartosz Gerard Gdaniec et al.
iScience, 25(1), 103669-103669 (2022-01-15)
Efficient delivery of toxic compounds to bacterial competitors is essential during interspecies microbial warfare. Rhamnolipids (RLPs) are glycolipids produced by Pseudomonas and Burkholderia species involved in solubilization and uptake of environmental aliphatic hydrocarbons and perform as biosurfactants for swarming motility.
Tulsidas G Shrivastav et al.
Journal of immunoassay & immunochemistry, 33(1), 1-17 (2011-12-21)
The introduction of spacers in coating steroid antigen or enzyme conjugates or immunogen is known to exert an influence on the sensitivity of steroid enzyme immunoassays. We have introduced different homobifunctional spacers having varying atomic length (3 to 10) between
U Heimgartner et al.
The Biochemical journal, 267(3), 585-591 (1990-05-01)
After periodate oxidation and incubation with a dihydrazide, cross-linking of the two heavy chains of immunoglobulins G from several species proceeds specifically through their oligosaccharides. We have used malonic acid dihydrazide, adipic acid dihydrazide and dithiodipropionic acid dihydrazide. The last
Lin-Song Li et al.
Pharmaceuticals (Basel, Switzerland), 14(2) (2021-02-03)
Functionalized gold nanoparticles (AuNPs) have been successfully used in many fields as a result of having low cytotoxicity, good biocompatibility, excellent optical properties, and their ability to target cancer cells. Here, we synthesized AuNP carriers that were modified by hyaluronic
Xuefeng Yang et al.
Carbohydrate polymers, 256, 117574-117574 (2021-01-24)
To meet the demands of various therapeutic tasks, injectable hydrogels with tunable mechanical properties and degradability are highly desired. Herein, we developed an injectable chitin hydrogel system with well-manipulated mechanical properties and degradability through dynamic acylhydrazone crosslinking catalyzed by 4-amino-DL-phenylalanine
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