A231
Arachidonyl trifluoromethyl ketone
oil, ≥97% (NMR)
Sinónimos:
1,1,1-Trifluoromethyl-6,9,12,15-heieicosatetraen-2-one, AACOCF3, Arach-CF3
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Fórmula empírica (notación de Hill):
C21H31F3O
Número CAS:
Peso molecular:
356.47
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
Servicio técnico
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Permítanos ayudarleQuality Level
assay
≥97% (NMR)
form
oil
storage condition
desiccated, protect from light, under inert gas
color
yellow
solubility
DMSO: >5 mg/mL
storage temp.
−20°C
SMILES string
CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)C(F)(F)F
InChI
1S/C21H31F3O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(25)21(22,23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3/b7-6-,10-9-,13-12-,16-15-
InChI key
PLWROONZUDKYKG-DOFZRALJSA-N
Gene Information
human ... PLA2G1B(5319)
Application
Arachidonyl trifluoromethyl ketone (AACOCF3) has been used as a anandamide degradation inhibitor to study its effects in primary astrocyte cultures.
Biochem/physiol Actions
Arachidonyl trifluoromethyl ketone (AACOCF3) plays a role in the inhibition of 12-hydroxyeicosatetraenoic acid (12-HETE) and thromboxane B2 produced by the platelets.
Inhibits anandamide hydrolysis in vitro; inhibits phospholipase A2.
Features and Benefits
This compound is featured on the Phospholipase A2 page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Disclaimer
Hygroscopic, photosensitive, air sensitive
Clase de almacenamiento
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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The endogenous cannabinoid anandamide potentiates interleukin-6 production by astrocytes infected with Theiler's murine encephalomyelitis virus by a receptor-mediated pathway
Molina H, et al.
Febs Letters, 433(1-2), 139-142 (1998)
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