A4034
(+)-Sodium L-ascorbate
powder, BioReagent, suitable for cell culture
Sinónimos:
L(+)-Ascorbic acid sodium salt, Vitamin C sodium salt
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Fórmula empírica (notación de Hill):
C6H7NaO6
Número CAS:
Peso molecular:
198.11
NACRES:
NA.75
PubChem Substance ID:
eCl@ss:
34058010
UNSPSC Code:
12352205
EC Number:
205-126-1
MDL number:
Beilstein/REAXYS Number:
3767246
Servicio técnico
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Permítanos ayudarlebiological source
synthetic (organic)
Quality Level
product line
BioReagent
assay
≥98%
form
powder
mol wt
Mw 198.11 g/mol
technique(s)
cell culture | mammalian: suitable, cell culture | plant: suitable
color
white to off-white
mp
220 °C (dec.) (lit.)
solubility
H2O: 50 mg/mL
SMILES string
[Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-]
InChI
1S/C6H8O6.Na/c7-1-2(8)5-3(9)4(10)6(11)12-5;/h2,5,7-10H,1H2;/q;+1/p-1/t2-,5+;/m0./s1
InChI key
PPASLZSBLFJQEF-RXSVEWSESA-M
General description
(+)-Sodium L-ascorbate (SA) is a potential antioxidant and is a derivative of vitamin C (L-ascorbic acid). It is widely used as a food additive. In addition, SA enhances growth retardation activity of bleomycin sulfate, R020-1724 (an inhibitor of cyclic nucleotide phosphodiesterase), prostaglandin E1 and sodium butyrate agents on neuroblastoma cells in culture. Elevated levels of SA induces two-stage urinary bladder carcinogenesis in rats. sodium L-ascorbate in combination with collagenogenesis inhibitors is used to treat dermal scars and keloids.
Application
(+)-Sodium L-ascorbate has been used:
- to produce H2O2 in cell culture media
- as a reducing agent for a cell-permeable artificial electron donor, N,N,N′,N′-tetramethyl-p-phenylenediamine (TMPD)
- to study its effect on production of collagen and elastic fibers in fibroblasts cultures derived from normal human skin and dermal fat
Used for preparation of plant extracts; reductant for the isolation of chloroplasts.
Biochem/physiol Actions
Antioxidant
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 1
ppe
Eyeshields, Gloves, type N95 (US)
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Sodium ascorbate potentiates the growth inhibitory effect of certain agents on neuroblastoma cells in culture
Prasad KN, et al.
Proceedings of the National Academy of Sciences of the USA, 76(2), 829-832 (1979)
Promoting effects of sodium L-ascorbate on two-stage urinary bladder carcinogenesis in rats
Fukushima S, et al.
Cancer Research, 43(9), 4454-4457 (1983)
Artefacts in cell culture: pyruvate as a scavenger of hydrogen peroxide generated by ascorbate or epigallocatechin gallate in cell culture media
Long LH and Halliwell B
Biochemical and Biophysical Research Communications, 388(4), 700-704 (2009)