A6816
(±)-AMPA
solid
Sinónimos:
(±)-α-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid hydrate
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Acerca de este artículo
Fórmula empírica (notación de Hill):
C7H10N2O4
Peso molecular:
186.17
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Form:
solid
Quality level:
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Permítanos ayudarleNombre del producto
(±)-AMPA, solid
InChI
1S/C7H10N2O4.H2O/c1-3-4(6(10)9-13-3)2-5(8)7(11)12;/h5H,2,8H2,1H3,(H,9,10)(H,11,12);1H2
SMILES string
O.Cc1onc(O)c1CC(N)C(O)=O
InChI key
HFISYNCCKQHIAM-UHFFFAOYSA-N
form
solid
color
white
solubility
H2O: 1 mg/mL (warm)
0.1 M HCl: 3.5 mg/mL
0.1 M NaOH: 4.3 mg/mL
DMSO: 4.3 mg/mL
1 M HCl: 50 mg/mL
Quality Level
Gene Information
Categorías relacionadas
Application
(±)-AMPA has been used:
- in vivo
- whole-cell patch-clamp recording in Müller glial cells
- to test its excitotoxic effects in hippocampal slice cultures
- in retinal horizontal cells (HCs) culture to test its effect on Ca2+ signals
Biochem/physiol Actions
Potent excitatory amino acid that interacts selectively with central AMPA/kainate receptors.
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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B W Kristensen et al.
Brain research, 917(1), 21-44 (2001-10-17)
The excitotoxic profiles of (RS)-2-amino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl)propionic acid (ATPA), (RS)-2-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA), kainic acid (KA) and N-methyl-D-aspartate (NMDA) were evaluated using cellular uptake of propidium iodide (PI) as a measure for induced, concentration-dependent neuronal damage in hippocampal slice cultures. ATPA is
Carlos Gonzalez-Islas et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(39), 13597-13607 (2012-09-28)
Endocannabinoid signaling has been shown to mediate synaptic plasticity by retrogradely inhibiting presynaptic transmitter release in several systems. We found that endocannabinoids act tonically to regulate AMPA miniature postsynaptic current (mPSC) frequency in embryonic motor circuits of the chick spinal
Mado Lemieux et al.
The Journal of cell biology, 198(6), 1055-1073 (2012-09-12)
The processing of excitatory synaptic inputs involves compartmentalized dendritic Ca(2+) oscillations. The downstream signaling evoked by these local Ca(2+) transients and their impact on local synaptic development and remodeling are unknown. Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is an important decoder
Frederic Lanore et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(49), 17882-17893 (2012-12-12)
The grik2 gene, coding for the kainate receptor subunit GluK2 (formerly GluR6), is associated with autism spectrum disorders and intellectual disability. Here, we tested the hypothesis that GluK2 could play a role in the appropriate maturation of synaptic circuits involved
Laura A DeNardo et al.
Neuron, 76(4), 762-775 (2012-11-28)
An important organizing feature of the CNS is that individual neurons receive input from many different sources. Independent regulation of synaptic input is critical for the function and adaptive responses of the nervous system, but the underlying molecular mechanisms are not
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