C4024

Carbamazepine

Name: Carbamazepine
Brand: SIGMA

≥98% (HPLC), powder, sodium channel inhibitor

Sinónimos:

5H-Dibenz[b,f]azepine-5-carboxamide

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About This Item

Fórmula empírica (notación de Hill):

C₁₅H₁₂N₂O

Número CAS:

298-46-4

Peso molecular:

236.27

UNSPSC Code:

12352200

eCl@ss:

34051404

PubChem Substance ID:

57654002

NACRES:

NA.77

EC Number:

206-062-7

MDL number:

MFCD00005073

Nombre del producto

Carbamazepine, powder

SMILES string

NC(=O)N1c2ccccc2C=Cc3ccccc13

InChI

1S/C15H12N2O/c16-15(18)17-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)17/h1-10H,(H2,16,18)

InChI key

FFGPTBGBLSHEPO-UHFFFAOYSA-N

form

powder

mp

191-192 °C (lit.)

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 29 mg/mL
H₂O: insoluble
ethanol: soluble
propylene glycol: soluble

originator

Novartis

storage temp.

2-8°C

Quality Level

100

Gene Information

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Categorías relacionadas

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

Application

Carbamazepine has been used to investigate its behavior in wastewater treatment and during groundwater infiltration. It has also been used to find out its effects on spontaneous seizures in rats.

Biochem/physiol Actions

Anticonvulsant; ligand for the GABA_A receptor benzodiazepine modulatory site. Sodium channel inhibitor.

Carbamazepine is considered as a safe antiepileptic drug. It decreases the multiple drug therapy and maintains a better control of epilepsy.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

GHS08,GHS07

signalword

Danger

hcodes

H302,H317,H334,H336,H360FD

pcodes

P202 - P261 - P280 - P301 + P312 - P302 + P352 - P308 + P313

Hazard Classifications

Acute Tox. 4 Oral - Repr. 1A - Resp. Sens. 1 - Skin Sens. 1A - STOT SE 3

target_organs

Central nervous system

Clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number

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Visite la Librería de documentos

Effect of antiepileptic drugs on spontaneous seizures in epileptic rats

Nissinen J and Pitkanen A

Epilepsy Research, 73(2), 181-191 (2007)

Carbamazepine as a possible anthropogenic marker in the aquatic environment: investigations on the behaviour of carbamazepine in wastewater treatment and during groundwater infiltration

Clara M, et al.

Water Research, 38(4), 947-954 (2004)

Role of carbamazepine in reducing polypharmacy in epilepsy

Maheshwari MC and Padmini R

Acta Neurologica Scandinavica, 64(1), 22-28 (1981)

NBI-921352, a first-in-class, NaV1.6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and rats.

J P Johnson et al.

eLife, 11 (2022-03-03)

NBI-921352 (formerly XEN901) is a novel sodium channel inhibitor designed to specifically target NaV1.6 channels. Such a molecule provides a precision-medicine approach to target SCN8A-related epilepsy syndromes (SCN8A-RES), where gain-of-function (GoF) mutations lead to excess NaV1.6 sodium current, or other

Graded doses of grape seed methanol extract attenuated hepato-toxicity following chronic carbamazepine treatment in male Wistar rats.

Opeyemi Samson Osuntokun et al.

Toxicology reports, 7, 1592-1596 (2020-12-12)

This study investigated the effects of co-administration of carbamazepine (CBZ) with grape (Vitis vinifera) seed methanolic extract (GSME) on liver toxicity. Thirty-five male rats (145-155 g) were randomized into 5 groups (n = 7) and administered with propylene glycol (PG

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