C8221
Caffeic acid phenethyl ester
synthetic, ≥97% (HPLC), Nuclear transcription factor NF-κB inhibitor, powder
Sinónimos:
CAPE
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Fórmula empírica (notación de Hill):
C17H16O4
Número CAS:
Peso molecular:
284.31
UNSPSC Code:
12352108
PubChem Substance ID:
NACRES:
NA.77
MDL number:
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Permítanos ayudarleNombre del producto
Caffeic acid phenethyl ester, ≥97% (HPLC), powder
SMILES string
Oc1ccc(\C=C\C(=O)OCCc2ccccc2)cc1O
InChI
1S/C17H16O4/c18-15-8-6-14(12-16(15)19)7-9-17(20)21-11-10-13-4-2-1-3-5-13/h1-9,12,18-19H,10-11H2/b9-7+
InChI key
SWUARLUWKZWEBQ-VQHVLOKHSA-N
biological source
synthetic
assay
≥97% (HPLC)
form
powder
storage condition
protect from light
color
off-white
solubility
ethyl acetate: 50 mg/mL, DMSO: soluble, ethanol: soluble
storage temp.
−20°C
Quality Level
Gene Information
human ... NFKB2(4791)
Categorías relacionadas
Application
Caffeic acid phenethyl ester (CAPE) has been used to determine the effect of CAPE in hyperthyroidism, as a component of culture media to measure the cytotoxicity of breast cancer cell line MDA-MB-231, to study its effects on amiodarone-induced pulmonary fibrosis in rats.
Biochem/physiol Actions
CAPE exhibits several properties such as anticarcinogenic, immunomodulatory activities, antioxidant, antiviral, anti-inflammatory, hypoglycaemic effect, cardioprotective and inhibits gastric secretion. It also has an inhibitory effect on fibroblasts growth factor type 2 (FGF-2), a tumor growth factor in breast cancer.
Caffeic acid phenethyl ester is a specific inhibitor of the nuclear transcription factor NF-κB.
Features and Benefits
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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The effect of propolis and its components on eicosanoid production during the inflammatory response.
O K Mirzoeva et al.
Prostaglandins, leukotrienes, and essential fatty acids, 55(6), 441-449 (1996-12-01)
To investigate the possible mechanism of the therapeutic action of propolis, we studied: (a) the effect of propolis, its components, caffeic acid phenethyl ester (CAPE), caffeic acid (CA), quercetin and naringenin, as well as the synthetic compounds indomethacin (IM) and
M R Fesen et al.
Proceedings of the National Academy of Sciences of the United States of America, 90(6), 2399-2403 (1993-03-15)
In an effort to further extend the number of targets for development of antiretroviral agents, we have used an in vitro integrase assay to investigate a variety of chemicals, including topoisomerase inhibitors, antimalarial agents, DNA binders, naphthoquinones, the flavone quercetin
Z Z Su et al.
Cancer research, 54(7), 1865-1870 (1994-04-01)
The active component of the honeybee hive product propolis, caffeic acid phenethyl ester (CAPE), induces a selective growth suppressive and toxic effect toward cloned rat embryo fibroblast cells transformed by adenovirus type 5 (Ad5) or the Ad5 E1A transforming gene
Migration rate inhibition of breast cancer cells treated by caffeic acid and caffeic acid phenethyl ester: an in vitro comparison study
Kabala-Dzik A, et al.
Nutrients, 9(10), 1144-1144 (2017)
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