C8982
α-Cyano-4-hydroxycinnamic acid
suitable for MALDI-TOF MS
Sinónimos:
α-CCA, α-CHCA, α-Cyano, 4-HCCA, ACCA
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Fórmula lineal:
HOC6H4CH=C(CN)CO2H
Número CAS:
Peso molecular:
189.17
UNSPSC Code:
12352106
NACRES:
NA.21
PubChem Substance ID:
EC Number:
248-879-1
Beilstein/REAXYS Number:
3271427
MDL number:
Form:
powder
Quality level:
Servicio técnico
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powder
Quality Level
analyte chemical class(es)
glycans, peptides, proteins
mp
245-250 °C (lit.)
suitability
suitable for MALDI-TOF MS
storage temp.
room temp
SMILES string
OC(=O)\C(=C\c1ccc(O)cc1)C#N
InChI
1S/C10H7NO3/c11-6-8(10(13)14)5-7-1-3-9(12)4-2-7/h1-5,12H,(H,13,14)/b8-5+
InChI key
AFVLVVWMAFSXCK-VMPITWQZSA-N
General description
α-Cyano-4-hydroxycinnamic acid (CHCA) is specially purified and qualified as a matrix for peptide MALDI-MS (matrix assisted laser desorption ionization-mass spectrometry) calibration standards. CHCA enhances ionization of protein or peptide standards and samples in matrix assisted laser desorption ionization (MALDI) mass spectrometers.
It is also available as part of our ProteoMass™ MALDI calibration kits (MS-CAL1 and MS-CAL3).
It is also available as part of our ProteoMass™ MALDI calibration kits (MS-CAL1 and MS-CAL3).
Application
α-Cyano-4-hydroxycinnamic acid has been used as a matrix for MALDI-TOF MS (matrix assisted laser desorption ionization-time of flight mass spectrometry) analysis. The matrix has also been used for sample preparation.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Legal Information
ProteoMass is a trademark of Sigma-Aldrich Co. LLC
signalword
Warning
hcodes
Hazard Classifications
Skin Sens. 1B
Clase de almacenamiento
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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We present a new MALD1 sample preparation technique for peptide analysis using the matrix alpha-cyano-4-hydroxy-cinnamic acid (CHCA) and prestructured sample supports. The preparation integrates sample purification, based on the affinity of microcrystalline CHCA for peptides, thereby simplifying the analysis of