E3889
Ethylene glycol-bis(2-aminoethylether)-N,N,N′,N′-tetraacetic acid
Molecular Biology, ≥97.0%
Sinónimos:
EGTA, Egtazic acid, Ethylene-bis(oxyethylenenitrilo)tetraacetic acid, Glycol ether diamine tetraacetic acid
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Fórmula lineal:
[-CH2OCH2CH2N(CH2CO2H)2]2
Número CAS:
Peso molecular:
380.35
UNSPSC Code:
12352106
NACRES:
NA.31
PubChem Substance ID:
EC Number:
200-651-2
Beilstein/REAXYS Number:
1717370
MDL number:
Servicio técnico
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Molecular Biology
Quality Level
assay
≥97.0%
form
powder
reaction suitability
reagent type: chelator
loss
≤1.0% loss on drying
mp
241 °C (dec.) (lit.)
foreign activity
DNAse (exonuclease), NICKase (endonuclease), RNAse, and protease, none detected
SMILES string
OC(=O)CN(CCOCCOCCN(CC(O)=O)CC(O)=O)CC(O)=O
InChI
1S/C14H24N2O10/c17-11(18)7-15(8-12(19)20)1-3-25-5-6-26-4-2-16(9-13(21)22)10-14(23)24/h1-10H2,(H,17,18)(H,19,20)(H,21,22)(H,23,24)
InChI key
DEFVIWRASFVYLL-UHFFFAOYSA-N
Application
A chelating agent useful for the determination of calcium in the presence of magnesium.
Ethylene glycol-bis(2-aminoethylether)-N,N,N′,N′-tetraacetic acid has been used:
- in Dulbecco′s phosphate-buffered saline (DPBS) to induce the weakening of cell-to-cell junctions
- as an extracellular calcium chelator to study the role of calcium in axonal mitochondria degeneration
- as a component in lysis buffer for lysing mouse mucosal cells for western blot analysis
Biochem/physiol Actions
Ethylene glycol tetraacetic acid (EGTA) can chelate calcium (Ca2+) at a ratio of 1:1. It serves as an anti-coagulant when dissolved at 1 g per 100 ml of blood. EGTA can prevent the vesicular release in the nanodomain of single Ca2+ channels. This metal chelator can inhibit the activity of pseudolysin.
Ethylene glycol-bis(2-aminoethylether)-N,N,N′,N′-tetraacetic acid A is a chelating agent used for the determination of calcium in the presence of magnesium.
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 2
ppe
Eyeshields, Gloves, type N95 (US)
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