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Merck

F0881

Fusidic acid sodium salt

≥98% (TLC), Bacterial protein synthesis inhibitor

Sinónimos:

Fucidin

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Fórmula lineal:
C31H47O6Na
Número CAS:
751-94-0
Peso molecular:
538.69
NACRES:
NA.77
PubChem Substance ID:
24278430
UNSPSC Code:
12352106
EC Number:
212-030-3
MDL number:
MFCD09054714
Assay:
≥98% (TLC)
Quality level:
200

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Nombre del producto

Fusidic acid sodium salt, ≥98% (TLC)

InChI

1S/C31H48O6.Na/c1-17(2)9-8-10-20(28(35)36)26-22-15-24(34)27-29(5)13-12-23(33)18(3)21(29)11-14-30(27,6)31(22,7)16-25(26)37-19(4)32;/h9,18,21-25,27,33-34H,8,10-16H2,1-7H3,(H,35,36);/q;+1/p-1/b26-20-;/t18-,21-,22-,23+,24+,25-,27-,29-,30-,31-;/m0./s1

InChI key

HJHVQCXHVMGZNC-JCJNLNMISA-M

SMILES string

[Na+].C[C@@H]1[C@H](O)CC[C@@]2(C)C1CC[C@@]3(C)C2[C@H](O)CC4\C([C@H](C[C@]34C)OC(C)=O)=C(/CC\C=C(\C)C)C([O-])=O

assay

≥98% (TLC)

solubility

H2O: soluble

antibiotic activity spectrum

neoplastics

mode of action

protein synthesis | interferes

storage temp.

2-8°C

Quality Level

200

Categorías relacionadas

General description

Fusidic acid is an antibiotic substance, resembling the structure of a steroid. It belongs to the class of fusidanes.

Application

Fusidic acid sodium salt has been used to study the effects of three-drug combinations on the growth rate of a bacterium, wild-type Escherichia coli. It is also used to study the in vitro susceptibility of dog-derived European methicillin-resistant Staphylococcus pseudintermedius and Staphylococcus aureus strains and their methicillin-susceptible counterparts.

Biochem/physiol Actions

Fusidic acid possesses antimicrobial action against skin pathogens. It is highly specific to Staphylococcus aureus. It is therefore used for treating infected traumatic wounds, folliculitis, furunculosis, impetigo, erythrasma and abscesses.
Suppresses nitric oxide lysis of pancreatic islet cells. Inhibits protein synthesis in prokaryotes by inhibiting the ribosome-dependent activity of G factor and translocation of peptidyl-tRNA.
Suppresses nitric oxide lysis of pancreatic islet cells; inhibits protein synthesis in prokaryotes.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Hazard Classifications

Acute Tox. 4 Oral

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
MKCS6501
MKCR7741
MKCP4072
MKCN3377
MKCM7015

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Enhanced identification of synergistic and antagonistic emergent interactions among three or more drugs
<BIG>Tekin E, et al.</BIG>
Journal of the Royal Society, Interface / the Royal Society, 20160332-20160332 (2016)
Fusidic acid in dermatology
British Journal of Dermatology, 37-40 (1998)
Susceptibility in vitro of canine methicillin-resistant and-susceptible staphylococcal isolates to fusidic acid, chlorhexidine and miconazole: opportunities for topical therapy of canine superficial pyoderma
<BIG>Clark SM, et al. </BIG>
The Journal of Antimicrobial Chemotherapy, 2048-2052 (2015)
Jürgen B Bulitta et al.
Antimicrobial agents and chemotherapy, 57(1), 498-507 (2012-11-14)
The objectives of this analysis were to develop a population pharmacokinetic (PK) model to describe the absorption and disposition of fusidic acid after single and multiple doses and to determine the effect of food on the rate and extent of
Anna C Shore et al.
Antimicrobial agents and chemotherapy, 56(10), 5340-5355 (2012-08-08)
One hundred seventy-five isolates representative of methicillin-resistant Staphylococcus aureus (MRSA) clones that predominated in Irish hospitals between 1971 and 2004 and that previously underwent multilocus sequence typing (MLST) and staphylococcal cassette chromosome mec (SCCmec) typing were characterized by spa typing
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