M0199

Mdivi-1

Name: Mdivi-1
Brand: SIGMA

≥98% (HPLC), powder, mitochondrial division DRP inhibitor

Sinónimos:

3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone, 3-(2,4-Dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone

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About This Item

Fórmula empírica (notación de Hill):

C₁₅H₁₀Cl₂N₂O₂S

Número CAS:

338967-87-6

Peso molecular:

353.22

UNSPSC Code:

12352200

PubChem Substance ID:

329817738

NACRES:

NA.77

MDL number:

MFCD00974506

Nombre del producto

Mdivi-1, ≥98% (HPLC), powder

SMILES string

COc1cc(N2C(S)=Nc3ccccc3C2=O)c(Cl)cc1Cl

InChI

1S/C15H10Cl2N2O2S/c1-21-13-7-12(9(16)6-10(13)17)19-14(20)8-4-2-3-5-11(8)18-15(19)22/h2-7H,1H3,(H,18,22)

InChI key

NZJKEVWTYMOYOR-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: >20 mg/mL

shipped in

wet ice

storage temp.

−20°C

Quality Level

100

Categorías relacionadas

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

Application

Mdivi-1 has been used:

in embryonic thoracic aorta A7r5 cells to inhibit cell migration and proliferation
in mitochondrial network reshaping and reactive oxygen species (ROS) production studies in oligodendrocyte precursor cells (OPCs)
to induce mitochondrial damage in lung fibroblasts

Biochem/physiol Actions

Mdivi-1 is a cell-permeable selective inhibitor of mitochondrial division DRP (dynamin-related GTPase) and inhibitor of the mitochondrial division dynamin (Dnm1). Mitochondrial fusion and division play important roles in the regulation of apoptosis. Mdivi-1 is the first selective inhibitor of mitochondrial division dynamins. In principle, Mdivi-1 represents a class of therapeutics for stroke, myocardial infarction, and neurodegenerative diseases.

Mdivi-1 is a selective inhibitor of mitochondrial division DRP (dynamin-related GTPase); inhibitor of the mitochondrial division dynamin (Dnm1).

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

General description

Mitochondrial Division Inhibitor 1 (Mdivi-1) is a quinazolinone derivative and is cell permeable. It traverses blood-brain barrier and elicits protective functionality in heart and brain ischemia-reperfusion injury.

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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To mdivi-1 or not to mdivi-1: Is that the question?

Smith G and Gallo G

Developmental neurobiology, 77(11), 1260-1268 (2017)

Increased mitochondrial fission is critical for hypoxia-induced pancreatic beta cell death.

Da Zhang et al.

PloS one, 13(5), e0197266-e0197266 (2018-05-17)

Hypoxia-mediated pancreatic beta cell death is one of the main causes of pancreatic beta celldeath, which leads to the loss of functional pancreatic beta cell mass and type 1 diabetes andtype 2 diabetes.However, the molecular mechanisms that control life and

The putative Drp1 inhibitor mdivi-1 is a reversible mitochondrial complex I inhibitor that modulates reactive oxygen species

Bordt EA, et al.

Developmental Cell, 40(6), 583-594 (2017)

Impaired mitophagy leads to cigarette smoke stress-induced cellular senescence: implications for chronic obstructive pulmonary disease

Ahmad T, et al.

Faseb Journal, 29(7), 2912-2929 (2015)

CoQ10 ameliorates mitochondrial dysfunction in diabetic nephropathy through mitophagy.

Jia Sun et al.

The Journal of endocrinology (2019-01-09)

The molecular signaling mechanisms of Coenzyme Q10 (CoQ10) in diabetic nephropathy (DN) remain poorly understood. We verified that mitochondrial abnormalities, like defective mitophagy, the generation of mitochondrial reactive oxygen species (mtROS) and the reduction of mitochondrial membrane potential, occurred in

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