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N0636

Nicotinamide

Name: Nicotinamide
Brand: SIGMA

BioReagent, suitable for cell culture, suitable for insect cell culture

Sinónimos:

Niacinamide, Nicotinic acid amide, Pyridine-3-carboxylic acid amide, Vitamin B₃, Vitamin PP

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Fórmula empírica (notación de Hill):

C₆H₆N₂O

Número CAS:

98-92-0

Peso molecular:

122.12

UNSPSC Code:

12352205

NACRES:

NA.75

PubChem Substance ID:

24897434

EC Number:

202-713-4

Beilstein/REAXYS Number:

383619

MDL number:

MFCD00006395

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Propiedades

biological source

synthetic (organic)

Quality Level

200

product line

BioReagent

assay

≥98% (HPLC)

form

powder

mol wt

M_w 122.12 g/mol

technique(s)

cell culture | insect: suitable, cell culture | mammalian: suitable

color

white

mp

128-131 °C (lit.)

solubility

water: soluble 50 mg/mL, clear, colorless

SMILES string

NC(=O)c1cccnc1

InChI

1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)

InChI key

DFPAKSUCGFBDDF-UHFFFAOYSA-N

Gene Information

human ... PARP1(142), SIRT2(22933)

Descripción

General description

Nicotinamide (NAM) belongs to vitamin B family and is the amide form of vitamin B3. NAM is present in food and is a constituent of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). Tryptophan is the precursor for NAM synthesis in liver. NAM controls cell metabolism, redox reactions, mitochondrial functionsand energy generation. It promotes natural killer cells proliferation and survival. NAM confers neuroprotection and promotes neuronal maturation. It has the ability to cross the blood-brain barrier and may provide protection in ischaemic stroke and traumatic brain injury. NAM may elicit therapeutic benefits in Alzheimer′s, Parkinson′s, and Huntington′s diseases.

Application

Nicotinamide has been used as a medium supplement in organoid culture of intestinal stem cells, esophageal squamous cell carcinomas(ESCC), pancreatic cancer organoids and pancreatic progenitor induction.

Biochem/physiol Actions

Nicotinamide is an amide derivative of vitamin B3 and a PARP inhibitor

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pictograms

GHS07

signalword

Warning

hcodes

H319

pcodes

P264 - P280 - P305 + P351 + P338 - P337 + P313

Hazard Classifications

Eye Irrit. 2

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 1

flash_point_f

302.0 °F - closed cup

flash_point_c

150 °C - closed cup

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Human Organoids Share Structural and Genetic Features with Primary Pancreatic Adenocarcinoma Tumors

Romero-Calvo I, et al.

Molecular Cancer Research, molcanres-molca0531 (2018)

The influence of nicotinamide on health and disease in the central nervous system

Fricker RA, et al.

International Journal of Tryptophan Research : IJTR, 11, 1178646918776658-1178646918776658 (2018)

Rapid prototyping of a multilayer microphysiological system for primary human intestinal epithelial culture

Hosic S, et al.

bioRxiv, 400721-400721 (2018)

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