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Merck

N151

Nisoxetine hydrochloride

≥98% (HPLC), Norepinephrine reuptake inhibitor, solid

Sinónimos:

(±)-γ-(2-Methoxyphenoxy)-N-methyl-benzenepropanamine hydrochloride, LY-94,939

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About This Item

Fórmula empírica (notación de Hill):
C17H21NO2 · HCl
Número CAS:
57754-86-6
Peso molecular:
307.82
UNSPSC Code:
12352200
PubChem Substance ID:
24277788
NACRES:
NA.77
MDL number:
MFCD00153850

Nombre del producto

Nisoxetine hydrochloride, solid, ≥98% (HPLC)

SMILES string

Cl[H].CNCCC(Oc1ccccc1OC)c2ccccc2

InChI key

LCEURBZEQJZUPV-UHFFFAOYSA-N

InChI

1S/C17H21NO2.ClH/c1-18-13-12-15(14-8-4-3-5-9-14)20-17-11-7-6-10-16(17)19-2;/h3-11,15,18H,12-13H2,1-2H3;1H

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

color

white to beige

solubility

H2O: 20 mg/mL
ethanol: 50 mg/mL

Quality Level

100

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Application

Nisoxetine has been used as a norepinephrine transport (NET) blocker in autoradiography studies. It has also been used as a NET blocker to study its effects on perivascular adipose tissue.

Biochem/physiol Actions

Nisoxetine is a selective and potent noradrenaline reuptake inhibitor. It has a high affinity towards the noradrenaline transporter. Nisoxetine possesses antidepressant activity.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
0000293783
0000293783
042M4604V
0000144840
0000144840

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Ching-I A Wang et al.
Molecular pharmacology, 82(5), 898-909 (2012-08-10)
The human norepinephrine transporter (NET) is implicated in many neurological disorders and is a target of tricyclic antidepressants and nisoxetine (NX). We used molecular docking simulations to guide the identification of residues likely to affect substrate transport and ligand interactions
S M Tejani-Butt
The Journal of pharmacology and experimental therapeutics, 260(1), 427-436 (1992-01-01)
The uptake sites for norepinephrine (NE) in brain have not been studied in much detail, probably due to the absence of an adequate radioligand for labeling these sites. This study describes the binding properties of [3H]nisoxetine to uptake sites for
B E Leonard
Neurochemistry international, 4(5), 339-350 (1982-01-01)
An attempt has been made to assess critically the clinical and experimental evidence that implicates a malfunctioning of amine neurotransmitter systems in the aetiology of depression. The evidence available does provide indirect evidence in favour of the biogenic amine theory
Adjmal Nahimi et al.
International review of neurobiology, 141, 251-274 (2018-10-14)
Noradrenergic neurons in both the peripheral nervous system and in the central nervous system (CNS) undergo severe degeneration in patients with Parkinson's disease (PD). This loss of noradrenaline may play essential roles in the occurrence of a wide range of
S M Tejani-Butt et al.
European journal of pharmacology, 191(2), 239-243 (1990-11-27)
[3H]Nisoxetine binds with high affinity (Kd = 0.7 nM) and selectivity to a homogenous population of sites associated with the uptake of norepinephrine. Specific [3H]nisoxetine binding to rat cortical homogenates was saturable, sodium-dependent and averaged 90% of total binding at
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