P0503
O-Phosphorylethanolamine
Sinónimos:
2-Aminoethyl dihydrogen phosphate, O-Phosphocolamine, O-Phosphoethanolamine, Colaminephosphoric acid
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About This Item
Fórmula lineal:
NH2CH2CH2OPO3H2
Número CAS:
Peso molecular:
141.06
UNSPSC Code:
12161700
NACRES:
NA.25
PubChem Substance ID:
EC Number:
213-988-5
Beilstein/REAXYS Number:
1758916
MDL number:
InChI key
SUHOOTKUPISOBE-UHFFFAOYSA-N
InChI
1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)
SMILES string
NCCOP(O)(O)=O
form
powder
storage temp.
−20°C
Quality Level
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Application
O-Phosphorylethanolamine has been used:
- in LHC-8 medium as a supplement in culturing the transformed human liver epithelial (THLE)-2 and THLE-3 cells
- in C-reactive protein (CRP) binding sucrose flotation experiment
- to incubate phosphomonoesters with anion-exchange chromatography (AEC) fractions for the detection of phosphatase activity
- to add in the washed beads for the preparation of phosphorylethanolamine (Pet) -conjugated sepharose column for chromatographic purification of mutant CRP
Biochem/physiol Actions
Phosphorylethanolamine participates in phospholipid metabolism. Its release can be stimulated occasionally by depolarizing stimuli. Reduction of phosphorylethanolamine levels has been observed in Alzheimer′s and Huntington′s disease.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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Phosphoethanolamine-complexed C-reactive protein: a pharmacological-like macromolecule that binds to native low-density lipoprotein in human serum
Singh SK, et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 394(1-2), 94-98 (2008)
The phosphocholine-binding pocket on C-reactive protein is necessary for initial protection of mice against pneumococcal infection
Gang TB, et al.
Test, jbc-M112 (2012)
Phosphoethanolamine and ethanolamine are decreased in Alzheimer's disease and Huntington's disease
Ellison David W, et al.
Brain Research, 417(2), 389-392 (1987)
Margaret N Holme et al.
Nature nanotechnology, 7(8), 536-543 (2012-06-12)
Atherosclerosis results in the narrowing of arterial blood vessels and this causes significant changes in the endogenous shear stress between healthy and constricted arteries. Nanocontainers that can release drugs locally with such rheological changes can be very useful. Here, we
Lin Zhu et al.
ACS nano, 6(4), 3491-3498 (2012-03-14)
A novel "smart" multifunctional drug delivery system was successfully developed to respond to the up-regulated matrix metalloprotease 2 (MMP2) in the tumor microenvironment and improve cancer cell-specific delivery of loaded drugs. The system represents a surface-functionalized liposomal nanocarrier, for which
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