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P1269

Phorbol 12,13-dibutyrate

≥98% (TLC), powder, PKC activator

Sinónimos:

PDBu

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Fórmula empírica (notación de Hill):
C28H40O8
Número CAS:
37558-16-0
Peso molecular:
504.61
NACRES:
NA.77
PubChem Substance ID:
24898178
UNSPSC Code:
12352211
MDL number:
MFCD00036783
Beilstein/REAXYS Number:
6551234
Assay:
≥98% (TLC)
Form:
powder
Quality level:
100
Servicio técnico
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Nombre del producto

Phorbol 12,13-dibutyrate, ≥98% (TLC), powder

Quality Level

100

assay

≥98% (TLC)

form

powder

color

clear light yellow

solubility

H2O: 30 μM, DMSO: soluble, acetone: soluble, ethanol: soluble

storage temp.

−20°C

SMILES string

CCCC(=O)O[C@@H]1[C@@H](C)[C@@]2(O)[C@@H](C=C(CO)C[C@@]3(O)[C@H]2C=C(C)C3=O)[C@@H]4C(C)(C)[C@]14OC(=O)CCC

InChI

1S/C28H40O8/c1-7-9-20(30)35-24-16(4)27(34)18(22-25(5,6)28(22,24)36-21(31)10-8-2)12-17(14-29)13-26(33)19(27)11-15(3)23(26)32/h11-12,16,18-19,22,24,29,33-34H,7-10,13-14H2,1-6H3/t16-,18+,19-,22-,24-,26-,27-,28-/m1/s1

InChI key

BQJRUJTZSGYBEZ-YVQNUNKESA-N

Gene Information

mouse ... Prkcd(18753)

Application

Phorbol 12,13-dibutyrate has been used as a protein kinase C (PKC) activator to study its effects on human organic anion transporter 4 (hOAT4) activity. It has also been used as a PKC activator to analyze its effects on galectin-3 expression and matrix production in HL-1 cells.

Biochem/physiol Actions

Phorbol 12,13-dibutyrate (PDBu) is a potent activator of protein kinase C (PKC). It is more hydrophilic than phorbol 12-myristate 13-acetate (PMA), which facilitates washing PDBu out of cells in tissue culture. PDBu activates endothelial nitric oxide synthase expression in primary human umbilical vein endothelial cells, which in turn correlates with PKC α and ε expression.

Features and Benefits

Less hydrophobic then PMA, making it easier to wash out of cells in tissue culture.

Preparation Note

Stock solution cannot be made in aqueous media; dissolve in a water-miscible organic solvent before dilution to working concentrations in aqueous media.

Disclaimer

Photosensitive

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Danger

Hazard Classifications

Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 2 Oral - Carc. 2 - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1

Clase de almacenamiento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
MKCZ2630
MKCX6860
MKCX2580
MKCX2528
MKCX1555

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Contenido relacionado

Product Information Sheet - P1269

Product Information Sheet

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Conventional and novel protein kinase C (PKC) isozymes contain two cysteine-rich C1 domains (C1A and C1B), both of which are candidate phorbol-12, 13-dibutyrate (PDBu)-binding sites. We synthesized C1 peptides of 50-70 residues corresponding to all PKC isozyme C1 domains using
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