P3972

Progesterone

Name: Progesterone
Brand: SIGMA

meets USP testing specifications

Sinónimos:

4-Pregnene-3,20-dione

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About This Item

Fórmula empírica (notación de Hill):

C₂₁H₃₀O₂

Número CAS:

57-83-0

Peso molecular:

314.46

UNSPSC Code:

41116107

NACRES:

NA.21

PubChem Substance ID:

24898476

EC Number:

200-350-6

Beilstein/REAXYS Number:

1915950

MDL number:

MFCD00003658

Nombre del producto

Progesterone, meets USP testing specifications

InChI key

RJKFOVLPORLFTN-LEKSSAKUSA-N

InChI

1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1

SMILES string

CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C

agency

USP/NF
meets USP testing specifications

assay

≥97%

form

solid

mp

128-132 °C (lit.)

application(s)

pharmaceutical (small molecule)

Quality Level

200

Gene Information

human ... ABCB1(5243), AR(367), CYP2C9(1559), EBP(10682), ESR1(2099), ESR2(2100), NR3C1(2908), NR3C2(4306), PGR(5241), SERPINA6(866)
mouse ... Esr1(13982)
rat ... Ar(24208), Nr3c1(24413), Pgr(25154)

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Biochem/physiol Actions

Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation. Progesterone is implicated in the etiology of breast cancer.

Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation.

Other Notes

Steroid hormone produced by the corpus luteum.

pictograms

GHS08

signalword

Danger

hcodes

H351,H360FD,H362

pcodes

P202 - P260 - P263 - P264 - P280 - P308 + P313

Hazard Classifications

Carc. 2 - Lact. - Repr. 1A

Clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Hippocampal volume and functional connectivity changes during the female menstrual cycle.

Nina Lisofsky et al.

NeuroImage, 118, 154-162 (2015-06-10)

Hippocampal volume has been shown to be sensitive to variations in estrogen and progesterone levels across rodents' estrous cycle. However, little is known about the covariation of hormone levels and brain structure in the course of the human menstrual cycle.

Growth Plate Borderline Chondrocytes Behave as Transient Mesenchymal Precursor Cells.

Koji Mizuhashi et al.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 34(8), 1387-1392 (2019-03-20)

The growth plate provides a substantial source of mesenchymal cells in the endosteal marrow space during endochondral ossification. The current model postulates that a group of chondrocytes in the hypertrophic zone can escape from apoptosis and transform into cells that

Premenopausal serum sex hormone levels in relation to breast cancer risk, overall and by hormone receptor status - results from the EPIC cohort.

Rudolf Kaaks et al.

International journal of cancer, 134(8), 1947-1957 (2013-10-25)

Results from prospective studies on premenopausal serum hormone levels in relation to breast cancer risk have been inconclusive, especially with regard to tumor subtypes. Using a case-control study nested within the prospective European Prospective Investigation into Cancer and Nutrition (EPIC)

Progesterone signalling in breast cancer: a neglected hormone coming into the limelight.

Cathrin Brisken

Nature reviews. Cancer, 13(6), 385-396 (2013-05-25)

Understanding the biology of the breast and how ovarian hormones impinge on it is key to rational new approaches in breast cancer prevention and therapy. Because of the success of selective oestrogen receptor modulators (SERMs), such as tamoxifen, and aromatase

HIV protease inhibitor use during pregnancy is associated with decreased progesterone levels, suggesting a potential mechanism contributing to fetal growth restriction.

Eszter Papp et al.

The Journal of infectious diseases, 211(1), 10-18 (2014-07-18)

Protease inhibitor (PI)-based combination antiretroviral therapy (cART) is administered during pregnancy to prevent perinatal human immunodeficiency virus (HIV) transmission. However, PI use has been associated with adverse birth outcomes, including preterm delivery and small-for-gestational-age (SGA) births. The mechanisms underlying these

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