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Merck

P6149

Progesterone

γ-irradiated, BioXtra, suitable for cell culture

Sinónimos:

4-Pregnene-3,20-dione

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Fórmula empírica (notación de Hill):
C21H30O2
Número CAS:
57-83-0
Peso molecular:
314.46
UNSPSC Code:
12352209
NACRES:
NA.77
PubChem Substance ID:
24898649
EC Number:
200-350-6
Beilstein/REAXYS Number:
1915950
MDL number:
MFCD00003658
Biological source:
synthetic (organic)
Form:
powder
Assay:
≥99%

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Nombre del producto

Progesterone, γ-irradiated, BioXtra, suitable for cell culture

form

powder

InChI key

RJKFOVLPORLFTN-LEKSSAKUSA-N

InChI

1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1

SMILES string

CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C

biological source

synthetic (organic)

description

synthesized from materials derived from plant source

sterility

γ-irradiated

product line

BioXtra

assay

≥99%

potency

0.1-20 ng/mL

technique(s)

cell culture | mammalian: suitable

mp

128-132 °C (lit.)

solubility

chloroform: 50 mg/mL, clear, colorless to light yellow

shipped in

ambient

storage temp.

room temp

Quality Level

200

Gene Information

human ... ABCB1(5243), AR(367), CYP2C9(1559), EBP(10682), ESR1(2099), ESR2(2100), NR3C1(2908), NR3C2(4306), PGR(5241), SERPINA6(866)
mouse ... Esr1(13982)
rat ... Ar(24208), Nr3c1(24413), Pgr(25154)

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Categorías relacionadas

Biochem/physiol Actions

Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation. Progesterone is implicated in the etiology of breast cancer.
Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation.

Other Notes

Steroid hormone produced by the corpus luteum.

Application

Use in cell culture applications to study sterol regulation of cell signaling and gene expression.

Physical form

powder-RT; stock-frozen in working aliquots, avoid repeated freeze/thaw

Preparation Note

To prepare 20 μg/ml stock solution, add 1 ml absolute ethanol, gently swirl to dissolve, add 49 ml sterile medium.

pictograms

Health hazard
GHS08

signalword

Danger

Hazard Classifications

Carc. 2 - Lact. - Repr. 1A

Clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificados de análisis (COA)

Lot/Batch Number
SLCQ9217
SLCQ9217
SLCN5986
SLCJ8249
SLCC3371

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Nina Lisofsky et al.
NeuroImage, 118, 154-162 (2015-06-10)
Hippocampal volume has been shown to be sensitive to variations in estrogen and progesterone levels across rodents' estrous cycle. However, little is known about the covariation of hormone levels and brain structure in the course of the human menstrual cycle.
Rudolf Kaaks et al.
Journal of the National Cancer Institute, 97(10), 755-765 (2005-05-19)
Contrasting etiologic hypotheses about the role of endogenous sex steroids in breast cancer development among premenopausal women implicate ovarian androgen excess and progesterone deficiency, estrogen excess, estrogen and progesterone excess, and both an excess or lack of adrenal androgens (dehydroepiandrosterone
Danijela Konforte et al.
Clinical chemistry, 59(8), 1215-1227 (2013-05-03)
Pediatric endocrinopathies are commonly diagnosed and monitored by measuring hormones of the hypothalamic-pituitary-gonadal axis. Because growth and development can markedly influence normal circulating concentrations of fertility hormones, accurate reference intervals established on the basis of a healthy, nonhospitalized pediatric population
Eszter Papp et al.
The Journal of infectious diseases, 211(1), 10-18 (2014-07-18)
Protease inhibitor (PI)-based combination antiretroviral therapy (cART) is administered during pregnancy to prevent perinatal human immunodeficiency virus (HIV) transmission. However, PI use has been associated with adverse birth outcomes, including preterm delivery and small-for-gestational-age (SGA) births. The mechanisms underlying these
Erika Comasco et al.
Human brain mapping, 35(9), 4450-4458 (2014-03-13)
Premenstrual dysphoric disorder (PMDD) is the prototypical sex-specific disorder in which symptom onset and offset require a particular hormonal milieu and for which there is moderate heritability. The present study investigated brain emotion processing in PMDD and healthy controls, as
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