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Merck

Q3251

Quinacrine dihydrochloride

≥90% (TLC), powder, MAO-A/B inhibitor

Sinónimos:

6-Chloro-9-(4-diethylamino-1-methylbutylamino)-2-methoxyacridine dihydrochloride, Atebrin dihydrochloride, Mepacrine dihydrochloride

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Fórmula empírica (notación de Hill):
C23H30ClN3O · 2HCl
Número CAS:
69-05-6
Peso molecular:
472.88
NACRES:
NA.77
PubChem Substance ID:
24278192
UNSPSC Code:
12352101
EC Number:
200-700-8
MDL number:
MFCD00012659
Beilstein/REAXYS Number:
4834013

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Nombre del producto

Quinacrine dihydrochloride, ≥90%

InChI key

UDKVBVICMUEIKS-UHFFFAOYSA-N

InChI

1S/C23H30ClN3O.2ClH/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23;;/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26);2*1H

SMILES string

Cl[H].Cl[H].CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc3ccc(OC)cc13

biological source

synthetic

assay

≥90%

form

powder

mp

257 °C

solubility

H2O: soluble, clear to hazy

originator

Bayer

Quality Level

100

Gene Information

human ... MAOA(4128), MAOB(4129)

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General description

Quinacrine is an acridine derivative and a potent antimalarial agent.

Application

Quinacrine dihydrochloride has been used:
  • in its uptake and accumulation studies in mouse lung slices using fluorescence microscope
  • in the staining of ATP vesicles in mesenchymal stem cells (MSCs)
  • in uptake-release assay for characterization of dense granule functionality of platelets

Biochem/physiol Actions

Non-selective MAO-A/B inhibitor.
Quinacrine has anthelmintic functionality and used in the female sterilization. It is used to treat systemic lupus erythematosus and rheumatic diseases. Apart from malaria, Quinacrine is effective for treating giardia and tapeworm infections. It inhibits nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity in addition to monoamine oxidase inhibition.

Features and Benefits

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

Stock solutions are stable for up to 60 h at 20°C.

Other Notes

This product is not assigned an expiration date or recommended retest date.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
BCCJ4898
BCCG8201
BCCD8591
BCCB2922
BCBV6879

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. Can Product Q3251, Quinacrine dihydrochloride be used for staining platelets?

    We have not tested Product Q3251, Quinacrine dihydrochloride for staining platelets. The reference link indicates that platelets can be visualized with the fluorescent dye mepacrine (quinacrine dihydrochloride) at a final concentration of 10 μM.  Brian Savage, et al., PNAS, 99 (1): 425-430, (2002).

  6. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

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Product Information Sheet - Q3251

Product Information Sheet

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