S0266
Spermidine
BioReagent, Molecular Biology, suitable for cell culture, ≥98%
Sinónimos:
1,8-Diamino-4-azaoctane, N-(3-Aminopropyl)-1,4-diaminobutane
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Fórmula lineal:
NH2(CH2)3NH(CH2)4NH2
Número CAS:
Peso molecular:
145.25
UNSPSC Code:
12352200
NACRES:
NA.52
PubChem Substance ID:
EC Number:
204-689-0
Beilstein/REAXYS Number:
1698591
MDL number:
Servicio técnico
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Molecular Biology
Quality Level
product line
BioReagent
assay
≥98%
form
solid or liquid
mol wt
145.25 (AMU)
technique(s)
cell culture | mammalian: suitable
refractive index
n20/D 1.479 (lit.)
density
0.925 g/mL at 25 °C (lit.)
foreign activity
DNase, RNase, and protease, none detected
storage temp.
room temp
SMILES string
NCCCCNCCCN
InChI
1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2
InChI key
ATHGHQPFGPMSJY-UHFFFAOYSA-N
Gene Information
rat ... Ppm1a(24666)
General description
Spermidine belongs to the natural polyamines, that are found in chloroplasts and in bacterial or eukaryotic cells.
Application
Spermidine is suitable for use in molecular biology buffers and for precipitation of DNA >100 bp in length. It was used to deliver DNA in plants and mammalian cells by particle bombardment technique.
Spermidine has been used in the preparation of gold beads and as a component in nuclei isolation buffer (NIB).
Biochem/physiol Actions
Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; Stimulates T4 polynucleotide kinase activity.
Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T4 polynucleotide kinase activity.
Spermidine helps to maintain the proper activity of gene expression. This polyamine plays a key role in intermediate metabolism. It also serves as an inhibitor of the acetyl transferase activity of E1A-associated protein p300 (EP300). Spermidine participates in cell growth.
Disclaimer
Solutions should be sterile-filtered, not autoclaved, if sterile solution is necessary. Spermidine deaminates with time; solutions should be stored frozen. Prepare new solutions frequently.
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Corr. 1B
Clase de almacenamiento
8A - Combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
233.6 °F - closed cup
flash_point_c
112 °C - closed cup
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
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Elumalai Sivamani et al.
Plant cell reports, 28(2), 213-221 (2008-11-19)
We have developed a method by which remarkably higher efficiencies of transient and stable transformation were achieved in bombardment transformation of plants. Over fivefold increase in transient gus gene expression was achieved when rice or maize suspension cells were bombarded
Spermidine delays aging in humans
Madeo F, et al.
Aging (Albany. NY.), 10(8), 2209-2209 (2018)
Delivery of DNA to skin by particle bombardment.
Shixia Wang et al.
Methods in molecular biology (Clifton, N.J.), 245, 185-196 (2004-01-07)