S8825
Salermide
≥98% (HPLC)
Sinónimos:
N-{3-[(2-Hydroxy-naphthalen-1-ylmethylene)-amino]-phenyl}-2-phenyl-propionamide
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Acerca de este artículo
Fórmula empírica (notación de Hill):
C26H22N2O2
Número CAS:
Peso molecular:
394.47
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
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Permítanos ayudarleInChI
1S/C26H22N2O2/c1-18(19-8-3-2-4-9-19)26(30)28-22-12-7-11-21(16-22)27-17-24-23-13-6-5-10-20(23)14-15-25(24)29/h2-18,29H,1H3,(H,28,30)/b27-17+
SMILES string
CC(C(=O)Nc1cccc(c1)\N=C\c2c(O)ccc3ccccc23)c4ccccc4
InChI key
HQSSEGBEYORUBY-WPWMEQJKSA-N
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
yellow
solubility
DMSO: >10 mg/mL
storage temp.
2-8°C
Quality Level
Categorías relacionadas
Application
Salermide was used to treat human pulmonary artery smooth muscle cells to study the effect of SIRT1 inhibition on expression of atrogin by qPCR.1
Biochem/physiol Actions
Salermide is a novel Sirtuin 1 (Sirt1) and Sirtuin 2 (Sirt2) inhibitor (III histone deacetylases inhibitor). In vitro Salermide has a stronger inhibitory effect on Sirt2 than on Sirt1. Salermide induces massive apoptosis in tumor cells. The activity was ascribed to effect of Salermide to the reactivation of proapoptotic genes epigenetically repressed exclusively in cancer cells by Sirt1. Salermide is a stronger Sirtuin inhibitor than sirtinol (Cat. No.S7942).
Salermide is a novel Sirtuin 1 (Sirt1) and Sirtuin 2 (Sirt2) inhibitor. Salermide reactivates proapoptotic genes epigenetically repressed exclusively in cancer cells by Sirt1.
Features and Benefits
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
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M Nikbakht Dastjerdi et al.
Research in pharmaceutical sciences, 8(2), 79-89 (2013-09-11)
Sirtuin1 (SIRT1) is an enzyme that deacetylates histones and several nonhistone proteins including p53 during stress and plays an important role in the survival of tumor cells. Hereby, this study describes the potency of salermide as a SIRT1 inhibitor to
Qi Zhang et al.
EMBO molecular medicine, 4(4), 298-312 (2012-02-15)
Although ∼50% of all types of human cancers harbour wild-type TP53, this p53 tumour suppressor is often deactivated through a concerted action by its abnormally elevated suppressors, MDM2, MDMX or SIRT1. Here, we report a novel small molecule Inauhzin (INZ)
Mohammad Reza Salahshoor et al.
International journal of preventive medicine, 4(12), 1402-1413 (2014-02-06)
Sirtuin1 is an enzyme that deacetylates histones and several non-histone proteins including P53 during the stress. P300 is a member of the histone acetyl transferase family and enzyme that acetylates histones. Hereby, this study describes the potency combination of Salermide
Julien Lancelot et al.
PLoS neglected tropical diseases, 7(9), e2428-e2428 (2013-09-27)
The chemotherapy of schistosomiasis currently depends on the use of a single drug, praziquantel. In order to develop novel chemotherapeutic agents we are investigating enzymes involved in the epigenetic modification of chromatin. Sirtuins are NAD+ dependent lysine deacetylases that are
Shan Huang et al.
Translational oncology, 10(6), 917-927 (2017-10-11)
Hepatocellular carcinoma (HCC) is one of the most common neoplasms, and metastasis is the most important feature for HCC-related deaths. Mounting evidence implies the dynamic regulatory role of SIRT2, a histone deacetylase, in cancer cells. Unfortunately, the role of SIRT2
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