S9396
Sphingomyelinase from Bacillus cereus
buffered aqueous glycerol solution, ≥100 units/mg protein (Lowry)
Sinónimos:
Sphingomyelin choline phosphohydrolase, Sphingomyelin phosphodiesterase
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Número CAS:
UNSPSC Code:
12352204
NACRES:
NA.54
MDL number:
Specific activity:
≥100 units/mg protein (Lowry)
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form
buffered aqueous glycerol solution
specific activity
≥100 units/mg protein (Lowry)
mol wt
34.2 kDa
foreign activity
Phospholipase C ≤1%
storage temp.
2-8°C
Gene Information
Bacillus cereus ATCC 10987 ... spH(2751530)
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General description
Sphingomyelinase (SMase) is a hydrolase, of 34.2 kDa and its active site contain as a minimum of two magnesium atoms.
Application
Sphingomyelinase from Bacillus cereus has been used:
- in the study to analyse the effect of sphingomyelinase on Rubella virus infectivity in cell lines
- in lipoprotein modification for the generation of cholesterol crystals in vitro
- to aggregate LDL (low-density lipoprotein)
Sphingomyelinase has been used in a study to assess the interaction of actin with the HIV-1 accessory protein Nef. Sphingomyelinase has also been used in a study to investigate X-ray scattering as a quality-control tool for liposomal drug-delivery systems.
Biochem/physiol Actions
Initiates the formation of sphingomyelin-based second messengers. Activates MAPK (mitogen-activated protein kinase) and SAPKs (stress-activated protein kinases); generates ceramide from sphingomyelin.
Sphingomyelin phosphodiesterase (SMPD) participates in the metabolic reactions comprising sphingomyelin. SMPD has the ability to prevent colorectal carcinoma and colitis.
Physical form
Solution in 50% glycerol containing 50 mM Tris-HCl, pH 7.5.
Other Notes
One unit will hydrolyze 1.0 μmole of TNPAL-sphingomyelin per min at pH 7.4 at 37 °C.
Clase de almacenamiento
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Analysis of the Effect of Sphingomyelinase on Rubella Virus Infectivity in Two Cell Lines
Otsuki N, et al.
Journal of virology (2017)
G Pabst et al.
European biophysics journal : EBJ, 41(10), 915-929 (2012-06-05)
Biological membranes can be targets for compounds that either disrupt their barrier function or affect protein function via membrane-mediated processes. Biophysical studies on membrane-mimetic systems composed of membrane lipids have contributed substantially to our knowledge on the pertaining membrane physics
The Bacillus cereus group
Molecular Medical Microbiology, 1041-1078 (2015)
Extracellular lipids accumulate in human carotid arteries as distinct three-dimensional structures and have proinflammatory properties
Lehti S, et al.
The American Journal of Pathology, 188(2), 525-538 (2018)
Characterization of Sphingomyelin Phosphodiesterase Expression in Bumblebee (Bombus lantschouensis)
Han L, et al.
Journal of Insect Science, 18(5), 20-20 (2018)
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