SAB2700181

Anti-NS3 antibody produced in rabbit

Name: Anti-NS3 antibody produced in rabbit
Brand: SIGMA

affinity isolated antibody, buffered aqueous solution

Sinónimos:

Dengue virus 2 Nonstructural protein NS3, Non-structure protein 3

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About This Item

NACRES:

NA.43

UNSPSC Code:

12352203

Nombre del producto

Anti-NS3 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

Dengue virus

technique(s)

flow cytometry: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
western blot: 500-3000

NCBI accession no.

NP_739587

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Application

Suggested starting dilutions are as follows: FACS: Assay-dependent dilution, ICC/IF: 1:100-1:2000, IHC: Assay-dependent dilution, IHC-P: Assay-dependent dilution, WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.
Anti-NS3 antibody produced in rabbit has been used in flow cytometry.

Biochem/physiol Actions

Non-structure protein 3 (NS3) along with NS2B play a vital role in proteolytic cleavage of dengue virus (DEN) non-structural proteins. NS3 also acts as a RNA-stimulated nucleoside-triphosphatase (NTPase)/RNA helicase and a 5′-RNA triphosphatase (RTPase).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

General description

Non-structure protein 3 (NS3), also known as dengue virus type 2 (DEN2), belongs to the Flaviviridae family. NS3 is a multifunctional protein with a molecular mass of about 69 kDa. It contains serine protease domain (NS3-pro) and it needs the hydrophilic domain of NS2B (NS2BH) for activation.

Immunogen

Recombinant protein fragment contain a sequence corresponding to a region within amino acids 354 and 568 of NS3 (Dengue virus 2) according to NP_739587

Physical form

1XPBS, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.

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pictograms

GHS07

signalword

Warning

hcodes

H317,H412

pcodes

P261 - P272 - P273 - P280 - P302 + P352 - P333 + P313

Hazard Classifications

Aquatic Chronic 3 - Skin Sens. 1

Clase de almacenamiento

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number

GT40786

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Dengue virus exploits autophagy vesicles and secretory pathways to promote transmission by human dendritic cells.

Alexandra P M Cloherty et al.

Frontiers in immunology, 15, 1260439-1260439 (2024-06-12)

Dengue virus (DENV), transmitted by infected mosquitoes, is a major public health concern, with approximately half the world's population at risk for infection. Recent decades have increasing incidence of dengue-associated disease alongside growing frequency of outbreaks. Although promising progress has

RIG-I-like receptor activation by dengue virus drives follicular T helper cell formation and antibody production.

Sprokholt JK, et al.

PLoS Pathogens, 13(11), e1006738-e1006738 (2017)

Both nonstructural proteins NS2B and NS3 are required for the proteolytic processing of dengue virus nonstructural proteins.

Falgout B, et al.

Journal of Virology, 65(5), 2467-2475 (1991)

RIG-I-like Receptor Triggering by Dengue Virus Drives Dendritic Cell Immune Activation and TH1 Differentiation.

Joris K Sprokholt et al.

Journal of immunology (Baltimore, Md. : 1950), 198(12), 4764-4771 (2017-05-17)

Dengue virus (DENV) causes 400 million infections annually and is one of several viruses that can cause viral hemorrhagic fever, which is characterized by uncontrolled immune activation resulting in high fever and internal bleeding. Although the underlying mechanisms are unknown

RIG-I?like Receptor Triggering by Dengue Virus Drives Dendritic Cell Immune Activation and TH1 Differentiation.