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Merck

SML0021

PDI inhibitor 16F16

≥98% (HPLC)

Sinónimos:

2-(2-Chloroacetyl)-2,3,4,9-tetrahydro-1-methyl-1H-pyrido[3,4-b]indole-1-carboxylic acid methyl ester, Methyl 2-(2-chloroacetyl)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate

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Fórmula empírica (notación de Hill):
C16H17ClN2O3
Número CAS:
922507-80-0
Peso molecular:
320.77
NACRES:
NA.77
PubChem Substance ID:
329825093
UNSPSC Code:
12352200
MDL number:
MFCD20134198
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100

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InChI key

BCSIRYFYAKLJDK-UHFFFAOYSA-N

SMILES string

COC(=O)C1(C)N(CCc2c1[nH]c3ccccc23)C(=O)CCl

InChI

1S/C16H17ClN2O3/c1-16(15(21)22-2)14-11(7-8-19(16)13(20)9-17)10-5-3-4-6-12(10)18-14/h3-6,18H,7-9H2,1-2H3

assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

DMSO: 12 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

Categorías relacionadas

Application

PDI inhibitor 16F16 may be used in protein disulfide isomerase-mediated cell signaling studies.
PDI inhibitor 16F16 has been used to inhibit PDI (protein disulfide isomerase) function to examine the functional conservation of PDIs in human embryonic kidney cells.

Biochem/physiol Actions

16F16 is a protein disulfide isomerase (PDI) inhibitor, first identified in a screen for compounds that prevent apoptosis induced by mutant huntingtin protein. 16F16 not only suppressed apoptosis induced by the misfolded protein mutant hungtingtin, it also protected rat neurons from cell death triggered by Aβ peptide. The actions of this inhibitor helped to identify a new mechanism in which a cell death pathway is regulated by protein misfolding via PDI upregulation.
Protein disulfide isomerase (PDI) inhibitor; suppresses apoptosis induced by misfolded proteins

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
0000503283
0000503280
0000503280
0000503283
0000407222

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Appropriate Wnt morphogen secretion is required to control animal development and homeostasis. Although correct Wnt globular structure is essential for secretion, proteins that directly mediate Wnt folding and maturation remain uncharacterized. Here, we report that protein disulfide isomerase-1 (PDI-1), a protein-folding
Ying Yuan et al.
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Patients with metastatic or relapsed/refractory osteosarcoma (OS) have a 5-year survival rate of <30%. This has remained unchanged over several decades. One of the factors contributing to lack of improvement in survival is the development of chemoresistance. Hence, elucidating and
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