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SML1072

GSK-LSD1

Name: GSK-LSD1
Brand: SIGMA

≥98% (HPLC), lysine specific demethylase 1 (LSD1) inhibitor, powder

Sinónimos:

GSK-LSD1 (trans-racemic) dihydrochloride, rel- N-[(1R,2S)-2-Phenylcyclopropyl]-4-Piperidinamine hydrochloride (1:2)

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Fórmula empírica (notación de Hill):

C₁₄H₂₀N₂ · 2HCl

Número CAS:

1431368-48-7

Peso molecular:

289.24

UNSPSC Code:

51111800

PubChem Substance ID:

329825454

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

powder

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Propiedades

Nombre del producto

GSK-LSD1, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H₂O: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

C1(N[C@@H]2C[C@H]2C3=CC=CC=C3)CCNCC1

InChI

1S/C14H20N2/c1-2-4-11(5-3-1)13-10-14(13)16-12-6-8-15-9-7-12/h1-5,12-16H,6-10H2/t13-,14+/m0/s1

InChI key

BASFYRLYJAZPPL-UONOGXRCSA-N

Descripción

Application

GSK-LSD1 has been used as a lysine specific demethylase 1 (LSD1) inhibitor in mice to study sepsis-induced mortality. It has also been used as an inhibitor to study if the effect of phenelzine activation of human immunodeficiency virus (HIV) latency is caused due to LSD1.

Biochem/physiol Actions

GSK-LSD1 is a potent and selective inhibitor of lysine specific demethylase 1 (LSD1). GSK-LSD1 potently inhibits proliferation of varies cancer cell lines by changing gene expression patterns. For full characterization details, please visit the GSK-LSD1 probe summary on the Structural Genomics Consortium (SGC) website.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

GSK-LSD1 is a potent and selective inhibitor of lysine specific demethylase 1.

Features and Benefits

GSK-LSD1 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Clase de almacenamiento

13 - Non Combustible Solids

flash_point_f

Not applicable

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