SRP3085
Interleukin-2, human
Animal-component free, recombinant, expressed in E. coli, suitable for cell culture
Sinónimos:
Aldesleukin, IL-2, T-cell growth factor (TCGF)
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Acerca de este artículo
NACRES:
NA.32
UNSPSC Code:
12352202
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Permítanos ayudarlebiological source
human
recombinant
expressed in E. coli
assay
≥95% (HPLC)
form
(Lyophilized with no additives from a 0.2µ filtered solution)
potency
≤0.5 ng/mL ED50
mol wt
15.5 kDa
packaging
pkg of 50 μg
technique(s)
cell culture | mammalian: suitable
impurities
≤1.00 EU/μg endotoxin, tested
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Quality Level
Gene Information
human ... IL2(3558)
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General description
IL-2 (interleukin 2) is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. It is a type I cytokine. The gene is mapped to human chromosome 4q27. Recombinant human IL-2 is a 15.5kDa protein, containing 134 amino acid residues including one intrachain disulfide bond.
Application
- IL-2 (interleukin 2) human has been used for the detection of IL-2 using 4-Fluoro-3-nitrophenyl grafted gold electrode based platform.
- It has been used for the production of tumor-specific cytotoxic T lymphocytes.
- It has been used for the proliferation of T lymphocytes.
Biochem/physiol Actions
IL-2/IL-2R (interleukin 2/IL-2 receptor) signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK (natural killer) cells, lymphokine activated killer cells, monocytes, macrophages and oligodendrocytes. It is associated with recurrent oral ulcer and asthma and Mycoplasma pneumoniae infection in children. Absence of IL2 in mice causes fatal lymphoproliferative inflammatory disease (IL-2 deficiency syndrome). IL-2 signaling involves three pathways: phosphoinositol 3-kinase (PI3-K)/AKT, Ras-MAPK (mitogen activated protein kinase), and JAK-STAT (Janus kinase - signal transducers and activators of transcription) pathways.
Physical form
Lyophilized with no additives.
Preparation Note
Reconstitute the contents of the vial using 100 mM acetic acid to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers and stored at 2-8 °C for up to 1 week. For extended storage, freeze in working aliquots. It may be advisable to centrifuge the vial prior to reconstitution.
Other Notes
MAPTSSSTKK TQLQLEHLLL DLQMILNGIN NYKNPKLTRM LTFKFYMPKK ATELKHLQCL EEELKPLEEV LNLAQSKNFH LRPRDLISNI NVIVLELKGS ETTFMCEYAD ETATIVEFLN RWITFAQSII STLT
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 1
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The common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 induce the expression of programmed death-1 and its ligands.
Kinter AL
Journal of Immunology, 181, 6738-6746 (2008)
4-Fluoro-3-nitrophenyl grafted gold electrode based platform for label free electrochemical detection of interleukin-2 protein.
Arya SK and Park MK
Biosensors And Bioelectronics, 61, 260-265 (2014)
A mechanism of hypoxia-mediated escape from adaptive immunity in cancer cells.
Barsoum IB
Cancer Research, 74, 665-674 (2014)
Prostaglandin E2 (PGE2)-dependent suppression of interleukin alpha (IL-2) production in patients with major trauma.
Faist E
The Journal of Trauma, 27, 837-848 (1987)
Family based association analysis of the IL2 and IL15 genes in allergic disorders.
Christensen U
European Journal of Human Genetics, 14, 227-235 (2006)
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