T8200
Tofisopam
≥98% (HPLC), solid
Sinónimos:
7,8-Dimethoxy-1-(3,4-dimethoxyphenyl)-5-ethyl-4-methyl-5H-2,3-benzodiazepine, EGYT 341, Seriel
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Acerca de este artículo
Fórmula empírica (notación de Hill):
C22H26N2O4
Número CAS:
Peso molecular:
382.45
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
244-922-3
MDL number:
Servicio técnico
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Permítanos ayudarleQuality Level
assay
≥98% (HPLC)
form
solid
drug control
regulated under CDSA - not available from Sigma-Aldrich Canada
color
white
solubility
DMSO: ~14 mg/mL, H2O: insoluble
SMILES string
CCC1C(C)=NN=C(c2ccc(OC)c(OC)c2)c3cc(OC)c(OC)cc13
InChI
1S/C22H26N2O4/c1-7-15-13(2)23-24-22(14-8-9-18(25-3)19(10-14)26-4)17-12-21(28-6)20(27-5)11-16(15)17/h8-12,15H,7H2,1-6H3
InChI key
RUJBDQSFYCKFAA-UHFFFAOYSA-N
Application
Tofisopam has been used for studying its biochemical mechanisms of actions using drug repositioning strategies.
Biochem/physiol Actions
Ligand for the GABAA receptor benzodiazepine modulatory site.
Studies have reported that tofisopam functions by blocking PDE4 (phosphodiesterase 4). Furthermore, the S-enantiomer of tofisopam is considered ten times more active than R-enantiomer.
Preparation Note
Tofisopam is soluble in DMSO at approximately 14 mg/ml. However, it is insoluble in water.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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P Bernard et al.
Current medicinal chemistry, 15(30), 3196-3203 (2008-12-17)
Drug repositioning strategy is an interesting approach for pharmaceutical companies; especially to increase their productivity. SELNERGY(tm) is a reverse docking based-program able to virtually screen thousands of compounds on more than 2000 3D biological targets. This program was successfully applied
[Grandaxin in neurological practice].
G M Diukova et al.
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 109(9), 44-48 (2009-11-17)
S M Leventer et al.
Alimentary pharmacology & therapeutics, 27(2), 197-206 (2007-11-02)
Dextofisopam modulates stimulated activity in animal models of stress, altered bowel motility, and visceral hypersensitivity. To evaluate the effects of dextofisopam in men and women with diarrhoea-predominant or alternating irritable bowel syndrome (IBS) (d-IBS or a-IBS). In this double-blind, placebo-controlled